N-(3,5-Dimethylphenyl)-3-Methoxybenzamide (A3B5) Targets TRP-2 and Inhibits Melanogenesis and Melanoma Growth

The study demonstrated that N-(3,5-Dimethylphenyl)-3-Methoxybenzamide (A3B5) significantly inhibited melanin production and moderately inhibited melanoma growth by targeting and degrading TRP-2. A3B5 reduced tumor size and weight by over 30% in mice and decreased melanoma cell proliferation by inducing G1 cell cycle arrest. The compound showed low cytotoxicity and effectively reduced UVB-induced pigmentation in guinea pigs. These findings suggested that A3B5 could be a potential therapeutic agent for treating hyperpigmentation and melanoma, though it may need to be combined with other treatments for effective melanoma therapy.