Androgenetic Alopecia as a Complication of SARS-CoV-2 Infection

The document is a literature review that synthesizes evidence correlating the role of androgens in androgenetic alopecia (AGA) in the context of SARS-CoV-2 infection. The study found that AGA, which is associated with hormonal variations due to the action of androgens, is being linked to severe COVID-19 prognoses and higher hospitalization rates. The SARS-CoV-2 infection occurs through the association between the virus's spike proteins and the host's transmembrane serine protease 2 (TMPRSS2), which facilitates the virus's entry into cells. Androgen receptors act as transcription promoters for TMPRSS2, making it easier for SARS-CoV-2 to enter cells. Variations in the androgen receptor gene are associated with its sensitivity and are linked to the development of conditions like AGA. The review also highlights the promising potential of anti-androgenic drug therapies in treating SARS-CoV-2 infections.