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Box A of HMGB1 can improve stem cell function, aiding anti-aging therapy.

Signals from skin cells controlled by Rac proteins help turn certain precursor cells into white fat cells.

The guide explains how to study human skin fat cells and their tissue, aiming to improve research and medical treatments.

Skin fat plays a key role in immune defense and healing beyond just storing energy.

Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.

Targeting the skin's endocannabinoid system could help treat skin disorders.

The research reveals how early embryonic mouse skin develops from simple to complex structures, identifying various cell types and their roles in this process.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Skin cell types develop when specific genes are turned on by removing certain chemical tags from DNA.

Fat tissue stem cells show promise for repairing different body tissues and are being tested in clinical trials.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

Some wound-healing cells can turn into fat cells around new hair growth in mice.

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

Understanding hair follicle biology and stem cell control could lead to new hair loss treatments.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

Advanced therapies like gene, cell, and tissue engineering show promise for hair regrowth in alopecia, but their safety and effectiveness need more verification.

Sebaceous glands are involved in various skin disorders, some treatable with medications like finasteride and minoxidil.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Using skin stem cells and certain molecules might lead to scar-free skin healing.

CD4+ skin cells may be precursors to basal cell carcinoma.

The conclusion is that accurately replicating the complexity of the extracellular matrix in the lab is crucial for creating realistic human tissue models.

Bimatoprost helps with hair growth and eye conditions but can be costly and have side effects.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.