103 citations,
October 2003 in “Birth Defects Research” Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.
102 citations,
January 2018 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Restoring hair bulb immune privilege is crucial for managing alopecia areata.
91 citations,
July 2015 in “Anais Brasileiros De Dermatologia” Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.
88 citations,
September 2013 in “Indian Journal of Dermatology, Venereology and Leprology” Minoxidil and finasteride effectively treat hair loss.
88 citations,
June 2009 in “Cleveland Clinic Journal of Medicine” To manage diffuse hair loss, identify the cause, improve nutrition, remove triggers, and use specific treatments like minoxidil or finasteride.
86 citations,
December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.
85 citations,
September 2013 in “International Journal of Molecular Sciences” Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.
66 citations,
July 2007 in “Journal of Molecular Medicine” Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.
64 citations,
August 1999 in “The American journal of medicine” The transscrotal testosterone patch normalizes hormone levels in men with AIDS and weight loss but does not improve weight, body mass, or quality of life.
60 citations,
March 2011 in “Proceedings of the National Academy of Sciences of the United States of America” RANK-RANKL signaling is essential for hair growth and skin health.
55 citations,
July 2016 in “Dermatologic Therapy” Multiple treatments work best for hair loss.
46 citations,
August 2016 in “Journal of Investigative Dermatology” New genes found linked to balding, may help develop future treatments.
45 citations,
September 2019 in “Dermatologic Therapy” Hair loss treatments work better with lifestyle changes.
42 citations,
March 2006 in “Drug Discovery Today: Therapeutic Strategies” The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.
34 citations,
April 2012 in “Journal of Dermatological Science” Hydrogen peroxide and monoethanolamine in hair dye can cause dermatitis and hair loss.
31 citations,
June 2008 in “Drug Discovery Today: Disease Mechanisms” Different hair growth problems are caused by genetic issues or changes in hair growth cycles, and new treatments are being developed.
30 citations,
December 2016 in “International Journal of Cosmetic Science” Hair loss in women links to inflammation around hair follicles.
24 citations,
June 2006 in “Skin Pharmacology and Physiology” Finasteride reverses early hair loss and promotes growth.
22 citations,
March 2008 in “Journal of Dermatological Science” EPR spectroscopy showed that spontaneous hair growth results in thicker skin and less pigmented hair than depilation-induced growth.
21 citations,
October 2017 in “Skin Pharmacology and Physiology” Caffeine-based liquid 0.2% is as effective as minoxidil 5% for treating male hair loss.
20 citations,
June 2010 in “Genes and Immunity” Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.
20 citations,
April 2005 in “Current Medicinal Chemistry” New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
15 citations,
September 2018 in “Dermatologic therapy” Both emollients effectively reduced itching and improved skin moisture in xerotic eczema.
13 citations,
March 2020 in “Genes” Disrupting the FGF5 gene in rabbits leads to longer hair by extending the hair growth phase.
11 citations,
January 2017 in “Journal of cell science” AGD1's PH domain is essential for its role in root hair growth and polarity.
10 citations,
March 2015 in “Journal of dermatology” The boy's severe skin disorder is caused by two new mutations in his TGM1 gene.
9 citations,
June 2000 in “Journal of The American Academy of Dermatology” Mutation in hairless gene may increase hair loss risk.
8 citations,
May 2022 in “Journal of medicine and life” COVID-19 patients may experience hair loss, but it's not linked to their age or sex.
8 citations,
January 2020 in “Skin appendage disorders” Saw palmetto supplements may modestly improve hair regrowth with few side effects, but more research is needed.
2 citations,
October 2021 in “Journal of Dermatological Treatment” Metabolic syndrome reduces effectiveness of hair loss treatment.