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GlossaryPreclinical Studies

laboratory and animal tests before human clinical trials

Preclinical Studies, also known as Preclinical Research or Preclinical Testing, are a phase of research conducted before clinical trials in humans. These studies involve laboratory experiments and animal testing to evaluate the safety, efficacy, and biological activity of a new drug or treatment. The goal is to gather enough data to determine whether the treatment is safe and promising enough to move on to human trials.

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Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

research Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

January 2023 in “Bioorganičeskaâ himiâ”

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

research Pantolactams as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

5 citations, September 2011 in “Bioorganic & Medicinal Chemistry Letters”

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

research Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

46 citations, September 2013 in “PLOS ONE”

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

research A Guide to the Use of Bioassays in Exploration of Natural Resources

January 2024 in “Biotechnology advances”

Bioassays help find useful compounds in nature for making medicines, supplements, and cosmetics.

research Regenerative Cosmetics: Skin Tissue Engineering for Anti-Aging, Repair, and Hair Restoration

July 2024 in “Cosmetics”

Regenerative cosmetics can improve skin and hair by reducing wrinkles, healing wounds, and promoting hair growth.

research Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates

1 citations, January 2024 in “Pharmaceuticals”

A new carrier improves skin delivery of tofacitinib for treating inflammatory skin diseases.

research Preclinical Evaluation of the Diabetic Wound Healing Activity of Phytoconstituents Extracted from Ficus Racemosa Linn. Leaves

August 2023 in “International journal of experimental research and review”

Ficus racemosa leaf extracts help heal diabetic wounds and lower blood sugar.

research Improving Selective Androgen Receptor Modulator Discovery and Preclinical Evaluation

11 citations, August 2009 in “Expert Opinion on Drug Discovery”

We need better ways to test and understand SARMs to make safer and more effective treatments.

research Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies

August 2024 in “Current Protocols”

The C3H/HeJ mouse model is useful for studying and testing treatments for alopecia areata.

research Drug Repurposing: A Promising Approach for Patients With Angina and Non-Obstructive Coronary Artery Disease (ANOCA)

June 2023 in “Frontiers in Cardiovascular Medicine”

Using existing drugs for new purposes could be a cost-effective way to treat chest pain and non-clogged heart arteries, with some drugs for lung blood pressure showing promise but needing more testing.

research Biomedical Applications of Organoids in Genetic Diseases

December 2024 in “Medical Review”

Organoids help study and treat genetic diseases, offering personalized medicine and therapy testing.

research 3D-SeboSkin Model for Human Ex Vivo Studies of Hidradenitis Suppurativa/Acne Inversa

4 citations, June 2021 in “Dermatology”

Scientists created a 3D skin model to study a chronic skin disease and test treatments.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations, August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Dynamic Evaluation of Pathological Changes in a Mouse Acne Model by Optical Imaging Technology

2 citations, May 2023 in “Experimental dermatology”

New imaging techniques can assess and track changes in mouse acne without harm, aiding treatment choices.

research Gene Therapy: Recent Advances and Applications in Dermatology

1 citations, October 1996 in “Journal of Cutaneous Medicine and Surgery”

Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.

Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations, June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research Formulation and Evaluation of Herbal Hair Serum: A Review

August 2023 in “International journal of basic and clinical pharmacology”

Herbal hair serum promotes natural hair growth and maintains healthy hair.

research Screening for Diabetes in Women with Polycystic Ovary Syndrome

3 citations, March 2007 in “Canadian Medical Association Journal”

Women with PCOS should have an oral glucose tolerance test for effective diabetes screening.

research Drug Repositioning: New Opportunities for Older Drugs

4 citations, January 2019 in “Elsevier eBooks”

Finding new uses for existing drugs is promising and can lead to safer, more effective medicines.

research Dutasteride Reduces Alcohol’s Sedative Effects in Men in a Human Laboratory Setting and Reduces Drinking in the Natural Environment

32 citations, February 2014 in “Psychopharmacology”

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

research Hair Follicle-Targeting Drug Delivery Strategies for the Management of Hair Follicle-Associated Disorders

14 citations, May 2022 in “Asian Journal of Pharmaceutical Sciences”

New hair follicle-targeting treatments show promise for hair disorders but need more research on safety and effectiveness.

Analyzing the Role of Tofacitinib in Treatment of Alopecia Areata: A Retrospective Analysis from a Tertiary Care Center of North India

research Analyzing the Role of Tofacitinib in Treatment of Alopecia Areata: A Retrospective Analysis from a Tertiary Care Center of North India

January 2023 in “National Journal of Physiology, Pharmacy and Pharmacology”

Tofacitinib effectively reduced hair loss in alopecia areata patients without adverse effects.

Evidence from a Humanized Mouse Model of Androgenetic Alopecia That Platelet-Rich Plasma Stimulates Hair Regrowth, Hair Shaft Diameter, and Vellus-to-Terminal Hair Reconversion In Vivo

research Evidence from a Humanized Mouse Model of Androgenetic Alopecia That Platelet-Rich Plasma Stimulates Hair Regrowth, Hair Shaft Diameter, and Vellus-to-Terminal Hair Reconversion In Vivo

March 2021 in “British Journal of Dermatology”

PRP helps hair regrowth and thickness.

research Improvement of Endothelial Function with Metformin and Rosiglitazone Treatment in Women with Polycystic Ovary Syndrome

56 citations, July 2008 in “European journal of endocrinology”

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Antagonism of NMDA Receptors as a Potential Treatment for Down Syndrome: A Pilot Randomized Controlled Trial

research Liposome-Based Carriers for CRISPR Genome Editing

August 2023 in “International Journal of Molecular Sciences”

Liposomes show promise for delivering CRISPR for gene editing but face challenges like delivery efficiency and safety concerns.

Weekly Docetaxel in Minimally Pretreated Cancer Patients: A Dose-Escalation Study Focused on Feasibility and Cumulative Toxicity of Long-Term Administration

research Weekly Docetaxel in Minimally Pretreated Cancer Patients: A Dose-Escalation Study Focused on Feasibility and Cumulative Toxicity of Long-Term Administration

50 citations, June 1999 in “Annals of Oncology”

Giving docetaxel weekly at 40 mg/m² is manageable and has low toxicity for cancer patients.

research Genotoxicity of Rice Bran Oil Extracted by Supercritical CO2 Extraction

7 citations, January 2014 in “Biological & pharmaceutical bulletin”

Rice bran oil extracted by supercritical CO2 is considered non-genotoxic.