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This article discusses the evolving landscape of dermatology, highlighting challenges pharmaceutical companies face with novel drug development, while smaller dermatology-focused companies lead in innovation; it reports no new results.

This review discusses advancements in skin microphysiological systems, such as 3D bioprinting, skin organoids, and skin-on-a-chip, and their effectiveness in emulating human skin functions for research and preclinical applications, highlighting the potential for replacing animal testing with these innovative technologies.

This review discusses methods for inducing polycystic ovary syndrome in animal models, with letrozole considered the easiest and most convenient for testing new treatments, but it reports no new clinical findings.

Innovative methods are reducing animal testing and improving biomedical research.

This study reports that C3H/HeJ mice and DEBR rats serve as effective models for screening potential treatments for human alopecia areata, despite certain challenges in predictability and cost.

This research developed new in vitro models for high-throughput screening of drugs that could protect or restore immune privilege in hair follicles, finding that Tofacitinib was effective in preventing inflammation-related marker upregulation, while Tacrolimus and αMSH worked specifically in outer root sheath keratinocytes.

This review discusses recent advances in understanding Merkel cell carcinoma biology, including the development of genetically-engineered mouse models and potential therapeutic targets, but reports no new clinical results.

This paper discusses two preclinical models for studying alopecia areata and finds that testing new therapeutic agents should involve both the C3H/HeJ mouse model and the humanized mouse model for comprehensive insights.

This review explores emerging 3D bioprinting strategies for hair follicle creation, highlighting their potential to advance alopecia treatment and trichology research, but notes the need for further optimization and reduced maintenance costs before clinical use.

This study presents a novel in vitro assay using human folliculoid microspheres to research hair growth, which may facilitate preclinical testing of hair growth-modulatory agents.

In this study, researchers developed a mouse model of non-healing wounds associated with streptozotocin-induced diabetes and found that it significantly delayed regenerative processes compared to healthy controls, suggesting its relevance for preclinical testing of wound regeneration drugs.

This study characterized the inflammatory response in a promising murine model of thermal burns, similar to human burns, to inform future burn complication studies and preclinical testing of therapies.

This study found that ionizing irradiation significantly inhibits proliferation and induces apoptosis in human hair follicle keratinocytes, suggesting its potential as a preclinical assay system for testing radioprotectants.

This study explored the use of "microfollicles," a human hair follicle organoid model, as an in vitro tool for testing hair-growth substances, finding up to 75% overlap in gene expression changes with human clinical biopsy responses to minoxidil, indicating its potential for pre-clinical substance testing.

This study reported that an ex vivo organ culture system effectively induced aging-related changes in healthy human skin, allowing testing of senolytics like tretinoin, resveratrol, and caffeine.

Stem cell therapies show promise for healing skin wounds but need more testing.

This study validated the HS 3D-SeboSkin model as a reliable tool for preclinical research, effectively preserving the structure and biomarker expression of lesional and perilesional HS skin ex vivo.

Exosomes might help hair regrow, but more human testing is needed.

This review discusses the antiviral potential of cepharanthine against SARS-CoV-2, noting its effectiveness in preclinical models but presenting no new clinical results.

Exosome therapies could help with skin and hair issues, but more testing is needed.

This study characterized the inflammatory response in a murine burn model, revealing similarities to human burns and supporting the model's use in testing therapies for burn complications.

This study developed a testosterone propionate-induced C57BL/6 mouse model of androgenetic alopecia, demonstrating that high-dose, prolonged testosterone administration inhibited hair regrowth and mirrored human AGA pathology, providing a useful platform for studying hair loss mechanisms and testing therapies targeting the Wnt/β-catenin pathway.

This study developed a triple drug delivery system using nanoparticles loaded with 5-fluorouracil, curcumin, and piperine to target breast tumors, demonstrating notable in vitro cytotoxicity and anti-metastatic potential in 3D tumor spheroids which suggests its promise for further preclinical evaluation.

Skin organoids can mimic human skin responses to injury and inflammation, making them useful for studying skin diseases and testing treatments.

This review discusses recent advancements made in using mouse models to investigate the genetic complexity and pathogenesis of alopecia areata, emphasizing potential new treatment targets, but it reports no new findings.

This paper discusses the limitations of clinical trials in evaluating combination treatment regimens for Alzheimer's disease and ischemic stroke, highlighting the extensive resources required for such trials.

This chapter discusses the synthesis and analysis of near-infrared fluorescent activity-based probes for imaging cysteine protease activity, reporting potential benefits for disease diagnosis but noting challenges in imaging specific locations with high cathepsin activity.

This review discusses various therapeutic strategies targeting platelet-derived growth factor signaling in diseases like cancer and atherosclerosis, and evaluates existing treatments without presenting new clinical data.

This study developed an animal model that recreates alopecia areata by injecting healthy human skin grafts in immunocompromised mice with peripheral blood mononuclear cells enriched for NKG2D+ and CD56+ cells.

This study found that echogenic liposomes improved the delivery and penetration of CRISPR/Cas9 genetic materials into cardiomyocytes, both in vitro and in vivo, especially when combined with ultrasound, highlighting a promising strategy for cardiovascular gene therapy.