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    Did you mean Potassium Channel Openers?
    Glossary Potassium Channel Openers

    drugs that activate potassium channels, aiding in cell stabilization

    Potassium Channel Openers (KCOs) are a class of drugs that activate potassium channels in cell membranes, allowing potassium ions to flow out of the cell. This action helps to stabilize the cell's electrical activity and can lead to muscle relaxation, vasodilation, and other physiological effects. They are used in various medical treatments, including managing hypertension and certain types of hair loss, such as androgenetic alopecia, by promoting blood flow and nutrient delivery to hair follicles.

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    1. Potassium channel openers: pharmacological and clinical aspects Fundamental & Clinical Pharmacology · 1992 · 119 citations
    2. Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for their Modes of Action in Hair Follicles Journal of Investigative Dermatology · 2005 · 35 citations
    3. Potassium Channel Openers Stimulate DNA Synthesis in Mouse Epidermal Keratinocyte and Whole Hair Follicle Cultures Skin Pharmacology and Physiology · 1993 · 31 citations
    4. Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the BN Rat Hypertension · 2013 · 28 citations
    5. Potassium channel openers: therapeutic potential in cardiology and medicine Expert Opinion on Pharmacotherapy · 2001 · 25 citations
    6. Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers? European journal of medicinal chemistry · 2014 · 6 citations
    7. Novel and established potassium channel openers stimulate hair growth in vitromodes of action in hair follicles.: implications for their 2005
    8. Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol–response curve in porcine detrusor muscle Arab Journal of Urology · 2012 · 3 citations
    9. Effects of Potassium Channel Modulators on the Responses of Mammalian Slowly Adapting Mechanoreceptors Social Science Research Network · 2022
    10. KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema Journal of Pharmacology and Experimental Therapeutics · 2020 · 18 citations
    11. Investigations into the roles of potassium channels in hair growth : studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches Bradford Scholars (University of Bradford) · 2010
    12. Pharmacological evidence for the involvement of adenosine triphosphate sensitive potassium channels in chloroquine-induced itch in mice Pharmacological Reports · 2017 · 9 citations
    13. Comparison of the effects of the K+-channel openers cromakalim and minoxidil sulphate on vascular smooth muscle British Journal of Pharmacology · 1991 · 33 citations
    14. K channel therapeutics at the bedside Journal of Molecular and Cellular Cardiology · 2005 · 119 citations
    15. Minoxidil suppressed mitochondrial depolarization and subsequent neuronal cell death by decreasing intracellular potassium level 日本薬理学会年会要旨集 = · 2018
    16. Minoxidil Use in Dermatology, Side Effects and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012 · 152 citations
    17. Therapeutic strategies for treating hair loss Drug Discovery Today: Therapeutic Strategies · 2006 · 42 citations
    18. Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action Dermatology · 2009 · 37 citations
    19. Nongenotoxicity of minoxidil in murine hair follicles as determined by the nuclear aberration assay Toxicology and Applied Pharmacology · 1988 · 12 citations
    20. Skin and hair abnormalities of Cantu syndrome: A congenital hypertrichosis due to a genetic alteration mimicking the pharmacological effect of minoxidil Journal of Dermatology · 2020 · 7 citations
    21. [Molecular approach of hair biology]. PubMed · 1994 · 6 citations
    22. Serious complication of low-dose oral minoxidil for hair loss JAAD case reports · 2022 · 1 citations
    23. Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells Journal of Dermatological Science · 1994 · 16 citations
    24. The Possible Involvement of KATP Channels in Cholestatic Pruritus in Mice Research Square (Research Square) · 2024
    25. Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome K<sub>ATP</sub>Channel Mutations in Intact Cells 2023 · 1 citations
    26. K <sub>ATP</sub> Channels and Cardiovascular Disease Circulation Research · 2013 · 144 citations
    27. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005 · 112 citations
    28. The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels Molecular pharmacology · 2022 · 5 citations
    29. Effect of K+ channel openers on K+ channel in cultured human dermal papilla cells. PubMed · 1997 · 20 citations
    30. The ATP sensitive potassium channel (KATP) is a novel target for migraine drug development Frontiers in Molecular Neuroscience · 2023 · 13 citations