Effects of Potassium Channel Modulators on the Responses of Mammalian Slowly Adapting Mechanoreceptors

    January 2022 in “ Social Science Research Network ”
    Peter Cahusac, Solomon S. Senok
    TLDR Potassium channel modulators mostly increase the activity of rat whisker mechanoreceptors.
    The study investigated the effects of various potassium (K+) channel modulators on the activity of slowly adapting mechanoreceptors in rat whisker pads. Using extracellular recordings, the researchers tested several K+ channel blockers and openers. Most blockers, except charybdotoxin and apamin, increased both spontaneous and evoked activities of the mechanoreceptors. Conversely, the channel opener NS1619 decreased evoked activity without significantly affecting spontaneous activity. These results suggest that K+ channels are crucial for maintaining spontaneous firing and mechanoreceptor activity. The study was funded by Alfaisal University, the Wellcome Trust, and the University of Stirling, with no conflicts of interest reported.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 70 results

      community Microneedling to maintain results from min

      in Microneedling  7 upvotes 1 month ago
      Microneedling alone is not effective in maintaining minoxidil results for hair growth. Combining microneedling with minoxidil and finasteride may enhance results, but microneedling by itself is not a reliable treatment.

      community Please explain this Minoxidil phenomena

      in Minoxidil  60 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community MY Hair Loss Treatment Summary

      in Treatment  8 upvotes 5 months ago
      The conversation is about various hair loss treatments, including finasteride, minoxidil, RU58841, and natural supplements like saw palmetto and pumpkin seed oil. It also covers methods to improve blood circulation, nourish hair follicles, and address underlying health issues like vitamin D deficiency and high cortisol levels.

    Similar Research

    5 / 1000+ results