May 2024 in “International journal of medicine and psychology.” This study examines the significant role genetic factors play in the development of intervertebral disc herniation and protrusion and explores how advancements in molecular genetics and translational medicine might improve diagnosis, prevention, and treatment, ultimately aiming to enhance patient outcomes and quality of life.
This study identified a 14,883 bp genomic deletion affecting the Plcd1 and Vill genes as likely responsible for the abnormal phenotype observed in snthr-1Bao mice.
January 2003 in “Springer eBooks” Certain genes are linked to type 1 and type 2 diabetes in kids, and changes in these genes can also cause other diabetes-related conditions.
November 2020 in “Journal of The American Academy of Dermatology” This study reported that using plain bottles instead of commercial kits for extracting platelet-rich plasma may be an effective method for treating hair loss.
124 citations
,
January 2009 This article provides an overview of crystallization processes, challenges, and applications, discussing various techniques and examples, but it reports no new experimental findings.
19 citations
,
July 2006 in “Acta crystallographica” This study determined that previous reports mistakenly identified different polymorphs of furosemide and finasteride, which are actually identical, due to incomplete data collection in single-crystal X-ray diffraction analysis.
March 2024 in “Skin research and technology” This study found that CRP levels were elevated in alopecia areata patients, with an inverse linear association between serum vitamin D and CRP levels specifically noted in ophiasis AA.
January 2022 in “Mammalian Genome” This study found that the wavy coat trait in Nakano cataract mice is polygenic, involving major and minor genes, and resembles human curly scalp hair associated with the PRSS53 gene alteration.
248 citations
,
August 2015 in “Pharmacological Research” This review discusses case reports of autoimmune diseases following vaccination and the challenges of establishing a clear epidemiological connection, urging further investigation into vaccine-induced autoimmunity.
191 citations
,
December 2003 in “Journal of Investigative Dermatology” Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.
71 citations
,
August 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This study revealed that human keratin-associated protein genes are expressed in specific patterns in hair fiber regions and vary in size, with some variations distinct across different populations.
70 citations
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October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review discusses the JAK-STAT pathway and the use of FDA-approved JAK inhibitors for autoimmune and inflammatory diseases but reports no new research findings.
65 citations
,
March 2017 in “Experimental Dermatology” This review discusses the genetic and biological factors influencing hair curliness, revealing strong links to specific protein variations, and reports no new clinical results.
51 citations
,
September 2012 in “Gene” In this study, researchers identified a putative ovine KAP24-1 gene in sheep, revealing four unique DNA sequences with some similarity to KRTAP24-1 sequences from other species.
29 citations
,
July 2012 in “Fertility and Sterility” This study observed that hepatotoxicity is a rare but possible event in hyperandrogenic young females treated with low- and ultralow-dose flutamide, regardless of dose or oral contraceptive use.
27 citations
,
February 2014 in “BMC Cancer” The EPICAP study aims to investigate various factors influencing prostate cancer, including circadian disruption, inflammation, hormonal and metabolic factors, and genetic susceptibility, and reports no new clinical results.
26 citations
,
October 2002 in “Journal of Investigative Dermatology” This study identifies a mutation in the hairless gene that may impact thyroid receptor interaction, contributing to alopecia universalis congenita in an Arab Israeli patient.
25 citations
,
April 2019 in “Animals” In this study, KRTAP28-1 variants were associated with wool fibre diameter in sheep, suggesting potential as a gene marker for reducing fibre diameter.
22 citations
,
September 2014 in “JAMA dermatology” This study identified major criteria including ectodermal malformations for diagnosing ichthyosis with confetti, and revealed significant genetic variation in the disease locus within the general population.
18 citations
,
January 2015 in “Experimental Dermatology” This study reports new monilethrix cases in Venezuela, the Netherlands, Belgium, and France, expanding the known mutational spectrum of the disorder with novel mutations in KRT81, KRT83, and KRT86 genes.
16 citations
,
January 2018 in “Advances in experimental medicine and biology” This review discusses the diversity of keratins and keratin-associated proteins in wool and hair, noting significant variation in their families, with no new results reported; the authors detail known protein structures without experimental findings.
12 citations
,
September 2017 in “Molecular and Cellular Endocrinology” This review analyzes how androgens impact sexual desire and reproductive behaviors, emphasizing molecular interactions, but provides no new clinical results.
10 citations
,
September 2022 in “Animals” This research identified 18 significant SNPs and several candidate genes associated with udder conformation traits in Holstein cattle, providing insights into their genetic architecture.
10 citations
,
September 2015 in “PLoS ONE” This case report documents a female toddler with novel compound heterozygous mutations in the VDR gene causing hereditary 1,25-dihydroxyvitamin D-resistant rickets, expanding the known mutation spectrum for this disease.
9 citations
,
October 2017 in “Archivos Argentinos de Pediatria” This review discusses the clinical features, diagnosis, and treatment of alopecia areata, while investigating potential genetic, environmental, and immunological factors involved in its etiology, but reports no new findings.
5 citations
,
October 2023 in “Forests” In this study, researchers assessed the genetic diversity of 101 Ginkgo biloba individuals using EST-SSR markers and concluded that there is a high level of genetic diversity in Ginkgo populations, facilitating the construction of a core germplasm collection for breeding purposes.
5 citations
,
May 2019 in “Archives of Dermatological Research” This study reported that narrowband UVB treatment significantly increased WNT7B, WNT10B, and TCF7L2 gene expression in lesional skin of psoriasis patients, suggesting these genes may play a role in psoriasis pathogenesis.
3 citations
,
November 2022 in “Frontiers in Oncology” This review discusses the role of melanin synthesis in melanoma, focusing on how melanosomal pH might regulate melanin production, and reports no new results.
3 citations
,
January 2022 in “Journal of Infection” This article discusses intra-host single-nucleotide variants in SARS-CoV-2, highlighting their potential to inform on virus strain diversity, immune escape, and drug design, but it reports no new clinical results.
1 citations
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April 2025 in “Animals” In this study, nucleotide sequence variation in the KRTAP13-3 gene was associated with changes in heterotypic hair fibre diameter variation in Chinese Tan sheep.