Vaccines, Adjuvants, and Autoimmunity

The review explored the relationship between vaccines, adjuvants, and autoimmunity, noting that while vaccines were effective in preventing diseases, they occasionally triggered autoimmune reactions, though these were rare and often transient. Aluminum adjuvants were highlighted for their potential role in inducing autoimmunity, leading to conditions like ASIA syndrome. Despite case reports, epidemiological studies did not establish a definitive link between vaccines and autoimmune diseases due to limited cases and varied symptoms. The review suggested further research in vaccinomics for personalized vaccine approaches. It also discussed the potential neurotoxic and immunotoxic effects of aluminum, its persistence in the body, and its possible role in autoimmune diseases. Genetic factors, such as HLA gene polymorphisms, were emphasized in influencing vaccine responses. While some vaccines were associated with autoimmune conditions, a direct causal relationship was often unproven, and genetic predisposition played a significant role. The need for further investigation into these associations was suggested to ensure vaccine safety and efficacy.