Crystallization of Organic Compounds: An Industrial Perspective
January 2009
TLDR Understanding and controlling crystallization is crucial for producing high-quality organic compounds in industry.
The document provided an industrial perspective on the crystallization of organic compounds, covering various aspects such as crystal properties, polymorphism, nucleation, growth kinetics, and critical issues in crystallization practice. It discussed different crystallization process options, including cooling, evaporative, antisolvent, and reactive crystallization, with examples illustrating each method. Special applications like the use of supercritical fluids, ultrasound, and computational fluid dynamics in crystallization were also explored. The document highlighted the importance of understanding solubility, supersaturation, and particle size distribution, as well as the impact of mixing on nucleation and crystal growth. It emphasized the need for strategic considerations in developing new crystallization processes, addressing regulatory issues, and ensuring product quality through controlled crystallization techniques.