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Isotretinoin is a preferred treatment for severe acne, often leading to long-term improvement, but requires careful monitoring due to potential side effects.

Metformin helps manage weight, blood pressure, and hormonal imbalances in PCOS patients.

Finasteride effectively treats male pattern baldness, improving hair growth and density.

Testosterone therapy can improve sexual satisfaction and mood in surgically menopausal women when used with estrogen, but its long-term safety and effects on naturally menopausal and premenopausal women are unclear.

Severe insulin resistance can be managed with medication, lifestyle changes, and treatment for related conditions.

Testosterone therapy can improve sexual function in women but long-term safety is unclear.

Belly fat is the main predictor of nonalcoholic fatty liver disease in both women with Polycystic ovary syndrome and healthy women.

Women with PCOS in North China often have hirsutism and acne, with hirsutism linked to metabolic issues.

The IRS-2 Asp/Asp genotype may increase the risk of PCOS in Chinese women, especially if they are not obese.

Certain gene variants in estrogen receptors are linked to polycystic ovary syndrome, mainly affecting metabolism, in Tunisian women.

Melatonin may help treat PCOS symptoms in rats.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Medications for PCOS don't seem to raise heart disease risk.

Melatonin improved mental health and metabolism in women with PCOS.

Xeno-free three-dimensional stem cell masses are safe and effective for improving blood flow and tissue repair in limb ischemia.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.

Polyurethane dressings show promise for wound healing but need improvements to adapt better to the healing process.

Nano-sized lipid particles increase dexamethasone's skin penetration and create a reservoir in the skin layers.

Finasteride effectively treats baldness but may cause sexual side effects.

Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.

Using rodents for research shows that health problems in the womb can cause diseases later in life.

Hormonal therapies, especially antiandrogens, can help manage Hidradenitis Suppurativa.

Solidified SEDDS improve drug stability and bioavailability better than liquid SEDDS.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

Insulin resistance is common in PCOS patients and linked to obesity and increased cardiovascular risk.

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

The document concludes that more research is needed to fully understand the causes of PCOS.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.