Type 2 Diabetes, Metabolic Syndrome, and Lipid Metabolism

    January 2014 in “ S. Karger AG eBooks ”
    Orit Pinhas-Hamiel
    Image of study
    TLDR Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.
    The document from 2014 discusses the prevalence, risks, and management of Type 2 Diabetes Mellitus (T2DM) in youth, with a study indicating a 0.36% prevalence among adolescents in the USA and a high rate of undiagnosed cases. The TODAY clinical trial with 699 obese 10- to 17-year-olds showed that while treatments like metformin plus rosiglitazone were safe, there was a high rate of treatment failure. T2DM was found to be more hazardous and lethal compared to Type 1 Diabetes Mellitus (T1DM), with higher mortality rates and complications. The document also explores the role of metformin in lifespan extension, a mutation in DYRK1B associated with Metabolic Syndrome (MetS), and the relationship between cortisol levels in hair and MetS. A study on prolactin levels in obese children suggested that prolactin could be a metabolic risk marker, with lifestyle interventions improving metabolic parameters. The document also reviews the 2013 ACC/AHA cholesterol guidelines, which recommend wider statin use, and the impact of mipomersen and evolocumab as lipid-lowering therapies. Mipomersen showed significant lipid reduction but had a high dropout rate due to side effects, while evolocumab was effective in reducing LDL-C levels with a low incidence of adverse events. Lastly, a humorous modeling study compared the effects of a statin a day to an apple a day on vascular mortality, suggesting that apples might offer similar benefits with fewer side effects.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 124 results

      community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

      in Research/Science  126 upvotes 2 years ago
      The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

      community MY Hair Loss Treatment Summary

      in Treatment  9 upvotes 5 months ago
      The conversation is about various hair loss treatments, including finasteride, minoxidil, RU58841, and natural supplements like saw palmetto and pumpkin seed oil. It also covers methods to improve blood circulation, nourish hair follicles, and address underlying health issues like vitamin D deficiency and high cortisol levels.

      community High Estrogen causing hair loss?

      in Treatment  15 upvotes 1 year ago
      A 24-year-old male using topical finasteride for hair loss is experiencing thinning despite treatment and has high estrogen levels. He is seeking advice on whether high estrogen could be causing hair loss and how others with high estrogen levels have addressed it.

      community Reminder how little the average person knows about hair loss

      in Satire  642 upvotes 1 year ago
      How little the average person knows about hair loss and how it can be an unfairly stigmatized issue, even by people with little knowledge of it themselves. Some specific treatments that were discussed include finasteride, RU58841, dutasteride, minoxidil, pyritinol, dermarolling, and diet/lifestyle changes.

      community Coffee and androgenetic alopecia

      in Research/Science  13 upvotes 1 year ago
      The conversation discusses a claim that avoiding coffee can lead to significant hair regrowth in individuals with androgenetic alopecia. Participants are skeptical, with some sharing personal anecdotes that contradict the claim, and others discussing the potential role of caffeine in hair loss and the effectiveness of other treatments like finasteride and minoxidil.

    Similar Research

    5 / 1000+ results