Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the roles of various PLA2 enzymes in skin health and disease, highlighting potential pathways for future diagnosis and therapy, but it reports no new clinical results.

This study reports that 2-(1-Adamantyl)-4H-thiochromen-4-on-6-O-sulfamate is the most potent steroid sulfatase inhibitor identified so far, exhibiting 170-fold higher activity than the lead compound estrone sulfamate.

This report describes two cases of thallium poisoning with gastrointestinal symptoms, peripheral neuropathy, and alopecia, which were effectively treated using activated charcoal, potassium chloride, and hemodialysis.

This study found that keratin films made from human hair can potentially substitute for human nail plates in drug permeability studies, but they show higher sensitivity to penetration enhancers compared to bovine hooves.

This study identifies the PI4P-RHD4 module as a key regulator of GET pathway receptor dynamics in Arabidopsis, affecting TA protein insertion and root hair growth.

This article reviews the risks of metal exposure from cosmetic products and emphasizes the need for stricter regulation and consumer awareness, without presenting new data or results.

This study found that prenatal exposure to fluoride and lead, as well as maternal micronutrient intake, may influence sexual maturation in adolescents in a sex-specific manner.

This study observed that chronic and acute exposure to finasteride negatively impacted development, reproduction, and gene expression in Daphnia magna, highlighting the environmental risks of this pharmaceutical for freshwater ecosystems.

This review discusses the essential roles and complex regulation of PP2A in various physiological processes and reports no clinical results; the authors highlight the need for further mouse model research to explore PP2A's therapeutic potential.

This study assessed the environmental impact of the drug finasteride on Daphnia magna, finding that both acute and chronic exposure impaired development and reproduction, affected gene expression and metabolism, and altered lipid profiles, highlighting the need to understand pharmaceutical impacts on aquatic ecosystems.

In this study, the novel fatty acid-conjugated tetrapeptide Palmitoyl-GDPH enhanced wound healing in rats by improving re-epithelialization and collagen deposition with minimal toxicity observed at the used dosage.

This study reports the development of a novel protocol to purify human TRPV3 ion channels, revealing functional properties and differences in ligand interactions, enabling further structural and functional research.

This study introduced a pH-responsive polymeric wound dressing that enhances healing in chronic wounds by changing shape and drug delivery based on wound pH, achieving a 94.88% healing rate in diabetic mice by day 14.

This review presents recent advancements in bio-degradable polymers made through green chemistry, highlighting eco-friendly raw materials and methods, while also identifying challenges and future research areas to enhance their sustainability and commercial viability.

This case report detailed a 38-year-old woman with thallium intoxication, who initially presented with polyneuropathy and alopecia. The diagnosis was confirmed by toxicology, and treatment with potassium hexacyanoferrate led to full recovery, underscoring the importance of early diagnosis and treatment in toxic polyneuropathies.

This study tested the acute toxicity of Ficus platyphylla methanol leaf extract in Wistar rats and found no mortality or significant liver enzyme changes at doses up to 5000 mg/kg, suggesting a high margin of acute safety and supporting its traditional use under short-term exposure.

This study found that using 1,4-butylenediamine bismaleimide for hair perming through thiol-Michael click chemistry offers comparable efficiency to conventional oxidative methods, with enhanced durability and reduced damage to hair fibres, preserving mechanical, color, and surface properties.

This review discusses the use of human and animal-derived placental and umbilical extracts in cosmetics, highlighting insufficient data to establish their safety and recommending they should not have metabolic or endocrine activity.

This study reports that both a 9-month-old with phenylketonuria on a phenylalanine-free diet and mice on a deficient diet exhibited severe health issues, highlighting the need for cautious dietary management.

This study developed a degradable and bioactive citrate-based polyurethane adhesive that achieves rapid and strong tissue adhesion, exhibiting improved bonding strength in wet environments, biocompatibility, biodegradability, and hemostatic properties, with potential to enhance wound healing by promoting angiogenesis.

Using testosterone-stimulated weanling rats can effectively replace castrated rats for anti-androgen testing, reducing animal stress.

This review highlights concerns about the potential negative effects of chemicals in cosmetic products on the health of pregnant women, fetuses, and newborns, stressing the need for more research.

This study found that the AtSfh1 protein in Arabidopsis is essential for phosphatidylinositol-4,5-bisphosphate signaling crucial to polarized root hair growth, utilizing both phosphatidylinositol and phosphatidylcholine-binding activities.

This study found that the methanol leaf extract of Ficus platyphylla demonstrated a high margin of acute safety in Wistar rats, showing minimal risk under short-term exposure with no mortality at doses up to 5000 mg/kg and no significant changes in liver enzyme activities.

This study found that Arabidopsis thaliana plants developed longer root hairs under low phosphorus conditions, suggesting auxin involvement in this adaptive response.

This study found that high doses of TCB caused severe toxicity in cotton top marmoset monkeys, with clinical and histological changes similar to those in humans and other primates exposed to PCBs.

New inhibitors may help treat hair loss by promoting fat cell growth in the skin.

This study found that overexpressing PLC5 in Arabidopsis thaliana reduced root growth but improved drought tolerance, and suggests PIP2 is crucial for root hair growth.

This review discusses the role of lysophosphatidic acid in skin physiology and pathology, highlighting its significance in processes like wound healing and hair follicle development, but reports no new clinical findings.