A Study of the Impact of Environmental Chemicals and Micronutrients on Pubertal Development in a Mexican Population

June 2017 in “ Deep Blue (University of Michigan) ”

Yun Liu

fluoride testosterone IGF-1 selenium zinc phosphorus riboflavin lead pubic hair growth genital development

TLDR Early exposure to fluoride, lead, and certain nutrients affects puberty differently in boys and girls.

This study investigated the impact of environmental chemicals and micronutrients on pubertal development using data from the ELEMENT cohorts in Mexico. It found that prenatal fluoride exposure was linked to reduced serum testosterone in boys and increased serum IGF-1 in girls during peripuberty. Maternal intake of selenium and zinc was associated with advanced pubic hair growth, while phosphorus and riboflavin intake was linked to advanced genital development in boys. Additionally, prenatal and early childhood lead exposure negatively affected pubertal development in girls. These findings suggested that early life exposure to fluoride, lead, and certain micronutrients could influence sexual maturation in a sex-specific manner, emphasizing the need for further research on environmental factors and pubertal disorders.

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A Study of the Impact of Environmental Chemicals and Micronutrients on Pubertal Development in a Mexican Population

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