5 citations
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January 2021 in “iScience” Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.
3 citations
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February 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that exposing adult esophageal epithelial cells to skin stroma can induce them to transition toward a hair follicle identity, with HIF1a playing a crucial role in this conversion process.
2 citations
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August 2024 in “Animal Bioscience” This study suggests that m6A-circHECA may influence the physiology of cashmere goats' SHFs both through miRNA pathways and interactions with target proteins, with promoter methylation potentially inhibiting its gene expression.
October 2024 in “International Journal of Biology Pharmacy and Allied Sciences” In this research, a thorough review of hair loss issues and treatments identified the effectiveness of minoxidil and finasteride for alopecia in the scalp's vertex region, but noted concerns about their potential long-term effects, leading to increased interest in herbal therapies.
January 2017 in “Qucosa (Saxon State and University Library Dresden)” This study found that plasma protein binding significantly contributes to the shifts in glucocorticosteroid concentration ratios among blood, saliva, and hair, challenging prior assumptions about enzyme inactivation as the main factor.
June 2022 in “Journal of Dermatology Research” This study found that 448-kHz Capacitive-Resistive Electrothermal Therapy led to a significant increase in hair density in women with Female Pattern Hair Loss, likely due to stimulated proliferation of dermal papilla cells.
1 citations
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December 2023 in “Scientific reports” This study investigated the use of 3D cell culture technology to explore hair follicle regeneration, examining the impact of the 3D cellular environment on hair follicle morphogenesis and the effects of microwell depth on spheroid formation.
This review reports that extracts from the plant Eclipta alba, traditionally used in herbal medicine, may promote hair growth by inhibiting TGF-β1 expression and functioning as a 5α-reductase inhibitor, potentially benefiting androgenic alopecia treatment.
70 citations
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September 2017 in “Expert opinion on therapeutic patents” This review examines the patent literature on AKR1C3 inhibitors and suggests that although numerous potent inhibitors exist, further preclinical optimization is necessary before assessing their therapeutic potential in human diseases.
June 2013 in “International Journal of Dermatology” This study found that among HIV-infected women, central lipohypertrophy was associated with shorter eyelashes but not changes in scalp hair texture or inflammation.
69 citations
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April 2010 in “Clinical ophthalmology” This article reviews the use of bimatoprost for eyelash hypotrichosis and reports its effectiveness in promoting eyelash growth but highlights uncertain efficacy in cases of eyelash alopecia areata.
1 citations
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December 2019 This study found that bimatoprost eye drops significantly increased eyelash length, thickness, pigmentation, and the number of eyelashes per follicle in rabbits within one month.
3 citations
,
September 2025 in “Neural Regeneration Research” This review discusses the roles of prostaglandins in the nervous system and their therapeutic potential for neurological diseases, noting their complex interactions with immune cells and signaling pathways.
1 citations
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December 2019 in “Clinical ophthalmology” This study found that bimatoprost eye drops increased eyelash length, thickness, pigmentation, and the number of eyelashes per follicle in rabbits, without causing inflammation.
This review concluded that the efficacy of cosmeceutical hair serums for addressing hair loss lies in their use of bioactive peptides and plant compounds, like flavonoids and sterols, that target eight key contributing factors identified in hair loss conditions.
January 2020 in “Indian Journal of Pharmaceutical Sciences” This review discusses rodent models of human hair loss and highlights the potential of traditional medicinal plants as hair growth promoters, but reports no new clinical results.
December 2022 in “Scientia Pharmaceutica” This study found that platelet-rich plasma (PRP) was more effective than minoxidil 5% topical treatment in increasing hair density for androgenic alopecia patients and had an additional benefit when combined with minoxidil.
12 citations
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February 2023 in “Stem Cell Research & Therapy” This study found that injecting hepatocyte growth factor-enhanced hair follicle stem cells into a rat model of ischemic stroke improved recovery by reducing inflammation, protecting the blood-brain barrier, and promoting angiogenesis.
1 citations
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September 2022 in “Evidence-based Complementary and Alternative Medicine” In this study, Gardenia florida fruit extract promoted hair growth in vitro and in vivo by enhancing hair growth-promoting gene expression and increasing hair follicle number, size, and depth in mice.
848 citations
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October 2020 in “International Journal of Molecular Sciences” This review discusses the potential of platelet-rich plasma applications in regenerative medicine and explores recent progress and challenges in translating non-clinical PRP findings into human treatments, but reports no new clinical results.
169 citations
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October 2020 in “Pharmaceutics” This review discusses recent advancements in formulating electrospun nanofibers as wound dressings, emphasizing their advantages in incorporating bioagents for improved healing, but reports no new clinical results.
45 citations
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August 2018 in “Stem Cells International” This article reviews the potential of adipose-derived and Wharton’s jelly stem cells in alopecia treatment but presents no new clinical findings, highlighting their potential benefits and limitations in regenerative medicine.
44 citations
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April 2023 in “Genes & Diseases” This review discusses the paracrine function of mesenchymal stem cells in tissue regeneration and repair, focusing on secreted bioactive substances and their role under different microenvironments; it reports no new clinical results.
41 citations
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June 2023 in “Antioxidants” This review highlights that pomegranate exhibits promising beneficial effects in preclinical and clinical studies for cardiovascular and non-cardiovascular diseases, though further research is needed on its bioavailability and metabolites for effective therapeutic use.
28 citations
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February 2021 in “Stem Cell Research & Therapy” This study found that conditioned medium from placental cells and sub-cultured placental tissue promoted angiogenesis in human umbilical vein endothelial cells in vitro, with early pregnancy cells having a more significant effect.
July 2024 in “Clinical Cosmetic and Investigational Dermatology” In this review, the authors summarized non-pharmacological therapies that may promote hair growth and regeneration as alternatives to traditional drug treatments and hair transplantation, both of which have notable limitations.
June 2024 in “Regenerative Therapy” This review highlights the potential of exosomes as a novel therapeutic approach for skin diseases and aging, due to their stability, transportability, and ability to carry various bioactive compounds to target cells.
April 2024 in “Pharmaceuticals” This review highlights the clinical usefulness of bimatoprost in lowering intraocular pressure for glaucoma patients and its promising results in promoting hair growth for conditions like alopecia, with research also exploring potential new applications and delivery systems.
April 2023 in “Dermatologica Sinica” This review examines the effects of sex hormones on hair growth and the pathogenesis of related hair disorders, highlighting current management benefits and controversies but reporting no new results.
January 2020 in “Global dermatology” This study investigated the effects of GFC with FGF5s and NMN at a depth of 0.8 mm using a microneedle for treating hair loss, but the abstract provides no measurable results.