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480-510 / 1000+ resultsresearch The PCOS Phenotypes in Unselected Populations (P-PUP) study: participant clinical features and data harmonization on analysis of individual participant data
The authors concluded that establishing and standardizing methods for data collection are crucial to improving PCOS diagnosis and research due to challenges observed in data harmonization across diverse international cohorts.
research Mitochondrial Oxygen Consumption and Immunocytochemistry of Human Dental Pulp Stem Cell Following 808 nm PBM Therapy: A 3D Cell Culture Study
This study found that 808 nm laser photobiomodulation altered mitochondrial respiration and enhanced osteogenic protein expression in human dental pulp stem cells, with the effects being dose-specific and more pronounced at 15 J/cm².
research First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide
This study found that PDRN derived from Lactobacillus rhamnosus showed superior antioxidant and wound-healing properties compared to salmon-derived PDRN, while also offering potential benefits in immune modulation and bioavailability.
research Impact of substrate stiffness on dermal papilla aggregates in microgels
This study observed that dermal papilla cell aggregates showed increased viability and gene expression on softer 3D substrates, indicating the importance of substrate stiffness in cellular behavior.
research An effective range of polydeoxyribonucleotides is critical for wound healing quality
In this study, classic PDRN (50-1,500 kDa) was observed to improve wound healing quality in a mouse model by enhancing collagen composition and cell migration.
research Polynucleotides HPT ‐Based Dermal Filler for Skin Rejuvenation: A Prospective Clinical Investigation
This study found that Plinest injections improved skin hydration and elasticity in the face, neck, and décolleté and were well-tolerated, with high patient satisfaction over a 4-month follow-up.
research DataSheet1_BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis.csv
This study found that downregulation of BBS7 in periodontal ligament cells was associated with reduced Sonic hedgehog signaling, which plays a crucial role in maintaining PDL homeostasis.
research Targeting the Hypoxic Microenvironment in Cutaneous Chronic Graft-Versus-Host Disease through PI3Kδ Inhibition
This study found that inhibiting the PI3Kδ enzyme in murine models of cutaneous chronic graft-versus-host disease (cGVHD) reduced skin scores and fibrosis, prevented pathogenic lymphoid structures, and improved survival, suggesting it as a promising therapeutic approach to address the disease's hypoxic pathophysiology.
research Platelet-rich plasma therapy: key infection prevention practices and strategies for safety risk reduction
This article discusses developing a standardized operating procedure for PRP administration to align with infection prevention regulatory standards and reports no new clinical results.
research Novel Mutations in X-Linked Dominant Chondrodysplasia Punctata (CDPX2)
This study analyzed patients with X-linked dominant chondrodysplasia punctata and identified novel mutations in the emopamil-binding protein gene, highlighting the need for genetic testing alongside biochemical analysis for accurate diagnosis.
research Patient prioritisation of items to develop the Patient‐Reported Impact of Dermatological Diseases measure: A global Delphi study
This study resulted in a draft version of the Patient‐Reported Impact of Dermatological Diseases measure, PRIDD, which includes 27 items refined from patient consensus and is now undergoing psychometric testing.
research 1380 PPAR-γ modulation as a novel therapeutic strategy for scarring alopecia
This study found that the PPAR-γ modulator AGED can reverse epithelial-mesenchymal transition in hair follicles affected by lichen planopilaris ex vivo, suggesting potential for treating scarring alopecias.
research rPanglaoDB: an R package to download and merge labeled single-cell RNA-seq data from the PanglaoDB database
This study introduced rPanglaoDB, an R package that facilitates the integration of public scRNA-seq datasets to effectively characterize rare cell types, exemplified by generating the first unbiased transcriptome profile of fibrocytes.
research Avaliação dos efeitos da finasterida sobre o desenvolvimento prostático intrauterino e pós-natal inicial de fêmeas e machos do gerbilo da Mongólia ("Meriones unguiculatus")
This study observed that intrauterine and early postnatal exposure to finasteride affected prostatic development in Mongolian gerbils, with significant sex-based differences, particularly higher alterations in female prostates.
research Perforins Expression by Cutaneous Gamma Delta T Cells
This review explores the expression of Perforin by gamma delta T cells in human skin and its role in cytotoxicity but reports no new experimental results.
research Pmg-1 and Pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development
This study identified two novel genes, pmg-1 and pmg-2, expressed in various skin and gland tissues and potentially involved in the differentiation of epithelial cells in epidermal appendages.
research A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds
In this study, a chronotherapeutic bilayer dressing system showed enhanced diabetic wound healing in a model by reducing inflammation through polyphenols and promoting repair with sustained PDGF-BB delivery, leading to faster re-epithelialization and hair follicle regeneration.
research Can Plasma Rich in Growth Factors Be Safe for Parental Use? A Safety Study in the Canine Model
This study found that intramuscular injections of a PRP-derivative in healthy beagle dogs did not result in statistically significant changes in lumbar muscle tissue or IGF-1 blood concentration, suggesting the treatment may be safe at therapeutic doses.
research 422 Human hair follicles express PD-L1, whose expression is down-regulated by EGFR and MEK inhibitors ex vivo. A potential mechanism for EGFR inhibitor induced sterile folliculitis
This study found that epidermal growth factor receptor and mitogen activated protein kinase inhibitors down-regulate PD-L1 expression in human hair follicles, which may contribute to sterile folliculitis in treated patients.
research Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates
The researchers reported that dPGS-PCL as a carrier improved the penetration of tofacitinib in an ex-vivo human skin model compared to free tofacitinib, but did not show significant differences in inhibiting IL-6 and IL-8 during short incubation.
research A small multigene hydroxyproline-O-galactosyltransferase family functions in arabinogalactan-protein glycosylation, growth and development in Arabidopsis
This study provides evidence that five Hyp-O-GALT genes are crucial for AGP galactosylation and that AGP glycans are vital for various aspects of plant growth and development.
research Human placental extract exerts hair growth-promoting effects through the GSK-3β signaling pathway in human dermal papilla cells
This study found that human placental extract promoted hair growth and influenced cellular pathways in vitro and rat models, suggesting potential for future hair loss treatments.
research Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging
This study identified a crucial role for epidermal Pgc-1α in regulating NAD+ signaling and influencing skin repair, with its dysfunction contributing to age-related wound healing defects.
research Finasteride-Induced Pseudoporphyria
Finasteride caused blisters on hands and feet.
research Pharmacodynamics and pharmacokinetics of P-3074, a new finasteride topical solution, administered at four different doses
P-3074 effectively blocks scalp DHT better than oral finasteride.
research Polydeoxyribonucleotide (PDRN) salmon sebagai agen anti penuaan
This article explores the potential mechanisms by which polydeoxyribonucleotide (PDRN) could improve skin quality, slow aging, and enhance skin regeneration, but reports no new clinical findings.
research Annual Meeting Symposia JPS Satellite Symposium Company Organized Symposia Young Scientist Symposia Joint Symposium with the Japanese Medical Science Federation Joint Symposium with the Physiological Society of Japan Joint Symposium with the Japanese Society of Toxicology Symposia
This discussion reviews the shift in pharmaceutical strategy towards evidence-based and structure-guided drug development, highlighting ongoing challenges and efforts in computer-aided drug design without presenting new clinical results.
research The role of PEDF in ageing and development: reduction of oxidative damage and support for stem cells
This review highlights pigment epithelium-derived factor's roles in ageing and development, focusing on its antioxidant functions and support of stem cell survival, but reports no new experimental results.
research Pretibial Pruritic Papular Dermatitis: A Case Report and Emphasis on Effective Treatment with Pentoxifylline
This report describes a 60-year-old female with pretibial pruritic papular dermatitis who showed significant improvement of skin lesions after one month of treatment with oral pentoxifylline. The authors highlight the unique clinical and histological features of PPPD and propose pentoxifylline as a potential therapy.