The Role of PEDF in Ageing and Development: Reduction of Oxidative Damage and Support for Stem Cells

This review discusses the multifunctional serpin protein, pigment epithelium-derived factor (PEDF), focusing on its roles in ageing and development. PEDF acts as an antioxidant through pathways like nicotinamide adenine dinucleotide phosphate oxidase and supports stem cell survival and differentiation, particularly in bone. Mesenchymal stem cells overexpressing PEDF significantly impact neighboring cells, offering therapeutic potential. Additionally, PEDF can modulate the p53 and peroxisome proliferator-activated receptor-gamma pathways. The review compiles a comprehensive overview of studies on PEDF, highlighting its significance in reducing oxidative damage and supporting stem cells.