The Role of PEDF in Ageing and Development: Reduction of Oxidative Damage and Support for Stem Cells

Pigment Epithelium-Derived Factor (PEDF) is highlighted for its antioxidative properties and support for stem cell survival and differentiation, particularly in bone, with implications for age-related diseases. It reduces oxidative damage through pathways like NADPH oxidase and influences cellular senescence and ageing. PEDF levels vary with age and are linked to conditions such as age-related macular degeneration and Alzheimer's disease. Notably, PEDF downregulation promotes hair follicle growth, suggesting its potential as a therapeutic target for androgenetic alopecia. Additionally, PEDF plays roles in reproductive health, retinal protection, and tissue development, underscoring its broad therapeutic potential.