99 citations
,
January 2004 in “Journal of Biological Chemistry” This study found that methylprednisolone can block IgG-induced keratinocyte detachment in an animal model of pemphigus vulgaris, potentially by increasing the synthesis and modifying adhesion molecules.
64 citations
,
December 2003 in “Veterinary Dermatology” This research observed that triamcinolone was more effective at inducing remission in cats with pemphigus foliaceus without significant side effects compared to prednisone or its combination with chlorambucil.
54 citations
,
November 1998 in “Archives of dermatology” This article discusses the potential role of nutritional ingredients, such as thiols and tannins, in triggering pemphigus, and reports no new empirical findings.
44 citations
,
May 2006 in “The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association” This study observed that combination therapy with prednisolone and azathioprine provided similar outcomes to prednisolone alone for treating pemphigus foliaceus in dogs, with over half achieving remission and significant improvement in another 25%.
35 citations
,
February 1993 in “International Journal of Dermatology” This report describes two cases where pemphigus lesions developed at sites of cosmetic procedures, suggesting these treatments might trigger the disease and should be distinguished from other post-surgery complications.
34 citations
,
March 2015 in “Clinical and Experimental Dermatology” This study observed that patients with pemphigus have a higher incidence of hypothyroidism, inflammatory bowel disease, and diabetes compared to the general population.
28 citations
,
May 1998 in “Journal of the American Academy of Dermatology” This case report suggests that tufted hair formation can occur in localized exudative inflammatory scalp lesions, as observed in a Japanese man with pemphigus vulgaris.
25 citations
,
July 1994 in “Archives of Dermatology” This study describes a patient with metastatic renal cell carcinoma who experienced a recurrence of pemphigus vulgaris after receiving interleukin 2 immunotherapy, suggesting a possible link between the treatment and autoimmune disease recurrence.
23 citations
,
November 2014 in “Anais Brasileiros de Dermatologia” This study suggests that trichoscopy may assist in diagnosing pemphigus, particularly for scalp-specific lesions, by identifying certain characteristic features.
23 citations
,
November 2011 in “Journal of the European Academy of Dermatology and Venereology” This study observed that in pemphigus vulgaris patients, hair loss and alopecic patches may result from anti-desmoglein autoantibody-mediated acantholysis and inflammatory changes, leading to non-scarring alopecia with potential for regrowth after treatment.
20 citations
,
March 1985 in “Journal of The American Academy of Dermatology” Genetic factors alone might not cause pemphigus vulgaris; other factors like birth complications and puberty may trigger it.
17 citations
,
April 2011 in “Journal of Dermatological Science” This study reports that the transgenic expression of Dsg1 in mice rescued the severe B6-Dsg3−/− phenotype and created a syngeneic mouse model of pemphigus vulgaris, which may aid in understanding autoimmunity mechanisms.
15 citations
,
January 2012 in “International Journal of Trichology” This case report describes dermoscopic features of pemphigus vulgaris on the scalp, highlighting that hair casts may suggest treatment adjustment for improved disease control.
15 citations
,
June 1992 in “Veterinary Dermatology” This case report describes an 8-year-old German shepherd dog with pemphigus vulgaris whose symptoms were not adequately controlled by immunosuppressive therapy, but showed transient remission with heparin alone or combined with prednisolone.
13 citations
,
January 2018 in “BioMed Research International” This review summarizes recent findings on scalp involvement in pemphigus vulgaris and pemphigus foliaceus, highlighting diagnostic methods and their underlying histopathological, immunopathological, and clinical features, but reports no new clinical results.
10 citations
,
November 2017 in “Advances in Dermatology and Allergology” This study found that scalp involvement in pemphigus is linked to greater disease severity and longer times to achieve both clinical and serological remission, suggesting it may require more aggressive treatment.
10 citations
,
October 2014 in “Journal of the European Academy of Dermatology and Venereology” This article discusses pemphigus vegetans of the scalp and references its clinical presentation and pathology, but it reports no new research findings.
9 citations
,
August 2002 in “Current Opinion in Pediatrics” This article discusses the roles of pediatrics and dermatology departments at Yale University School of Medicine, but reports no specific clinical results.
9 citations
,
June 2017 in “Journal of Cutaneous Pathology” This study found that follicular acantholysis is a common histopathological feature in pemphigus, with differences in depth between pemphigus vulgaris and pemphigus foliaceus lesions that may aid in diagnosis.
9 citations
,
June 2017 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study suggests that local skin inflammation may enhance the deposition of autoantibodies in the skin, potentially affecting the severity of pemphigus lesions in mice.
7 citations
,
July 2017 in “The Journal of Dermatology” This letter to the editor notes a case where alopecia developed as pemphigus foliaceus transitioned to pemphigus vulgaris; it provides no new experimental findings.
7 citations
,
January 2009 in “Indian Journal of Dermatology Venereology and Leprology” Hair changes may indicate disease activity in pemphigus patients.
5 citations
,
October 2015 in “The American journal of pathology” This study found that a spontaneous deletion in the Dsg3 gene of mice leads to hypomorphic desmoglein 3 expression, resulting in severe immunodeficiency, cyclic hair loss, and wasting disease, without causing the blistering typical of pemphigus vulgaris.
4 citations
,
August 2017 in “International journal of molecular sciences” This study observed two cases of pigmented epithelioid melanocytoma suggesting potential differing origins: one from a hair follicle's outer root sheath and another from an intradermal nevus.
4 citations
,
October 2003 in “PubMed” This study in a rat model found that dietary rehabilitation with a high protein diet reversed symptoms of kwashiorkor, suggesting a role for free radicals in its development.
3 citations
,
May 2024 in “International Journal of Dermatology” In this study, pediatric pemphigus was found to have a chronic but mostly benign progression, with initial remission from corticosteroids typically requiring additional immunomodulators for long-term control, and the authors advocate for using rituximab in these cases.
3 citations
,
June 2019 in “Veterinary record case reports” This case report describes a miniature dachshund with pustular dermatitis and other symptoms, developing pemphigus foliaceus after receiving afoxolaner, which was effectively managed with prednisone and cyclosporine.
2 citations
,
May 2023 in “Biology” This study developed and characterized new mouse models of Pemphigus that mimic different forms of the disease, but treatment with Methyl-Prednisolone showed only partial effectiveness.
2 citations
,
January 2025 in “Journal of Oncology Pharmacy Practice” This case study reports a rare instance of pembrolizumab-induced eyelash trichomegaly in a 63-year-old male patient, highlighting the importance for clinicians to be aware of such uncommon adverse effects to manage patient treatment effectively.
2 citations
,
March 2023 in “Frontiers in Medicine” This case study presented a 16-year-old male with dermatosis neglecta and obsessive-compulsive disorder, where his skin condition improved after proper cleansing and psychiatric treatment, suggesting that DN may also indicate underlying psychiatric issues.