Pemphigus Foliaceus in 91 Dogs
May 2006
in “
The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association
”
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Studysummary This study observed that combination therapy with prednisolone and azathioprine provided similar outcomes to prednisolone alone for treating pemphigus foliaceus in dogs, with over half achieving remission and significant improvement in another 25%.
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This retrospective study of 91 dogs with pemphigus foliaceus found that the most common clinical signs were crusts, pustules, and alopecia, with lesions primarily on the trunk, inner pinnae, face, and foot pads. Cytological evaluation showed acantholytic keratinocytes in 37 of 48 dogs. Treatment with prednisolone alone or in combination with azathioprine resulted in remission for more than half of the dogs, with an additional 25% showing significant improvement. Adverse effects were more common with combination therapy. The study concluded that both treatment regimens were effective, but combination therapy had a higher incidence of side effects.
