TLDR Both treatments for pemphigus foliaceus in dogs are effective, but combination therapy has more side effects.
This retrospective study of 91 dogs with pemphigus foliaceus found that the most common clinical signs were crusts, pustules, and alopecia, with lesions primarily on the trunk, inner pinnae, face, and foot pads. Cytological evaluation showed acantholytic keratinocytes in 37 of 48 dogs. Treatment with prednisolone alone or in combination with azathioprine resulted in remission for more than half of the dogs, with an additional 25% showing significant improvement. Adverse effects were more common with combination therapy. The study concluded that both treatment regimens were effective, but combination therapy had a higher incidence of side effects.
105 citations,
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