A Case of Pemphigus Vulgaris Developing After Platelet-Rich Plasma Treatment

In 2019, a case was reported of a 42-year-old woman who developed Pemphigus Vulgaris (PV), a chronic autoimmune bullous disease of the skin and mucous membranes, after receiving Platelet-rich Plasma (PRP) treatment for female pattern hair loss. The first lesions of PV appeared on the scalp, the site of PRP application, and later spread to other areas of the skin and mucous membranes. The diagnosis of mucocutaneous PV was confirmed through clinical, cytological, and serological findings. While PRP has been used to treat various conditions, including alopecia and chronic nonhealing wounds, this was the first known case of PRP-related PV. The report suggested that PRP might trigger acantholysis in genetically susceptible patients, leading to PV. However, it was also noted that there was not enough evidence to definitively link PRP to PV. The report concluded that PRP treatment should be performed with caution.