Local Inflammation Exacerbates Cutaneous Manifestations in a Murine Autoimmune Pemphigus Model
June 2017
in “
The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology
”
local inflammation cutaneous manifestations autoantibodies epidermis pemphigus PMA UVB irradiation tape-stripping intravital microscopy flow cytometry autoimmune skin conditions skin inflammation skin symptoms antibodies skin phorbol 12-myristate 13-acetate ultraviolet B light live imaging cell analysis autoimmune skin diseases
TLDR Local inflammation worsens autoimmune skin conditions by increasing antibody buildup.
The study demonstrated that local inflammation significantly enhanced the deposition of autoantibodies in the epidermis in a murine model of pemphigus. Using inflammatory stimuli like PMA application, UVB irradiation, and tape-stripping, researchers observed increased antibody deposition in inflamed skin compared to non-inflamed skin, confirmed through intravital microscopy and flow cytometry. A subpathogenic dose of a pathogenic antibody induced pemphigus lesions only in inflamed areas. These findings suggested that local inflammation could exacerbate autoimmune skin conditions by promoting autoantibody deposition, potentially informing diagnostic and therapeutic strategies for pemphigus. Statistical significance was determined with a P value of less than .05.
