Scalp Involvement in Pemphigus: A Prognostic Marker

    November 2017 in “ Advances in Dermatology and Allergology ”
    Marta Sar‐Pomian, Marek Konop, Kamila Gala, Lidia Rudnicka, Małgorzata Olszewska
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    Studysummary This study found that scalp involvement in pemphigus is linked to greater disease severity and longer times to achieve both clinical and serological remission, suggesting it may require more aggressive treatment. Our plain-language summary of this paper — not a Tressless recommendation.
    Scalp involvement in pemphigus was observed in 65.2% of patients with pemphigus vulgaris and 96.6% of patients with pemphigus foliaceus. The study of 75 patients found that scalp involvement correlated with higher disease severity (r = 0.7, p < 0.05), longer time to achieve complete clinical remission (39.1 ±47.1 months vs. 9.1 ±7.8 months), and shorter duration of remission (14.1 ±17.4 months vs. 105.7 ±108.8 months). Additionally, patients with scalp involvement had higher concentrations of anti-desmoglein 1 autoantibodies (109.9 ±68.0 U/ml vs. 21.3 ±39.4 U/ml). These findings suggested that scalp involvement in pemphigus indicated a need for a more aggressive therapeutic approach.
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