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    Glossary Pain Mediator

    substance that transmits and modulates pain signals in the body

    A pain mediator, also known as a pain signaling molecule, is a substance in the body that plays a crucial role in the transmission and modulation of pain signals. These molecules, such as prostaglandins, bradykinin, and substance P, are released in response to injury or inflammation and interact with nerve receptors to amplify the sensation of pain. Understanding pain mediators is essential for developing effective pain management therapies.

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    1. Lysophospholipid Mediators in Health and Disease Annual review of pathology · 2021 · 49 citations
    2. Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study Aesthetic Surgery Journal · 2019 · 7 citations
    3. Increased expression of nerve growth factor and neurokinin-1 alarm the hair loss in female with trichodynia Journal of The American Academy of Dermatology · 2012
    4. Hair casts Journal of The American Academy of Dermatology · 2012
    5. The role of sleep in telogen effluvium and trichodynia: A commentary in the context of the current pandemic Journal of Cosmetic Dermatology · 2021 · 6 citations
    6. Fatty acids and related lipid mediators in the regulation of cutaneous inflammation Biochemical Society Transactions · 2018 · 28 citations
    7. Hair Pain (Trichodynia): Frequency and Relationship to Hair Loss and Patient Gender Dermatology · 2002 · 48 citations
    8. Indications for Peripheral and Central Sensitization in Patients With Chronic Scalp Pain (Trichodynia) The Clinical Journal of Pain · 2012 · 16 citations
    9. Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity Frontiers in Immunology · 2025
    10. Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses Journal of Investigative Dermatology · 2018 · 26 citations
    11. Montagna Symposium 2016—The Skin: Our Sensory Organ for Itch, Pain, Touch, and Pleasure 2017 · 1 citations
    12. Sensitive scalp: does this condition exist? An epidemiological study Contact Dermatitis · 2008 · 80 citations
    13. Variables affecting the potential efficacy of PRP in providing chronic pain relief Journal of Pain Research · 2018 · 71 citations
    14. ACNE Dermatologic Clinics · 1997 · 58 citations
    15. Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States Frontiers in Immunology · 2021 · 50 citations
    16. Multiple minute digitate hyperkeratosis Journal of the European Academy of Dermatology and Venereology · 2002 · 9 citations
    17. Transgender and Migraine Headache · 2019 · 7 citations
    18. Adverse effects of platelet-rich plasma and microneedling Journal of The American Academy of Dermatology · 2019 · 3 citations
    19. GPCRs as key regulators in wound healing Frontiers in Cell and Developmental Biology · 2026
    20. Das weiße Hautfettgewebe initiiert die IL-33-abhängige Expression von Interleukin 4/13 in myeloischen Zellen während einer Entzündung Qucosa (Saxon State and University Library Dresden) · 2024
    21. Nociceptive and Nonnociceptive Roles of TRPV3 and Its “Druggability” Methods in pharmacology and toxicology · 2012
    22. Intradiscal platelet-rich plasma for discogenic low back pain: a prospective cohort study of early clinical outcomes and quantitative MRI findings Scientific Reports · 2026 · 1 citations
    23. Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors 2018 · 16 citations
    24. Body image mediates the impact of pain on depressive symptoms in patients with systemic lupus erythematosus Lupus · 2019 · 9 citations
    25. Sanhuang Fukang oil alleviates X-ray-induced skin injury by reducing inflammation and apoptosis: an in vivo study Frontiers in Pharmacology · 2026
    26. Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis 2024
    27. Peptide-Based Approaches for Pain Relief and Healing in Wounds International Journal of Molecular Sciences · 2026
    28. Time Perspective as a Mediator of Depressive Symptoms in Patients with Polycystic Ovary Syndrome Healthcare · 2023 · 1 citations
    29. PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology Experimental Dermatology · 2019 · 24 citations
    30. Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice Pharmaceuticals · 2024 · 2 citations