Acute Toxicity Studies and Evaluation of Analgesic Property of Tectona Grandis Methanolic Seed Extract in Swiss Albino Mice
September 2019
in “
Asian Journal of Pharmaceutical and Clinical Research
”
Studysummary In this study, researchers found that the methanolic seed extract of Tectona grandis, known for its use in traditional medicine, demonstrated strong analgesic properties in Swiss albino mice, being effective at doses of 200–250 mg/kg and safe up to 1000 mg/kg. Our plain-language summary of this paper — not a Tressless recommendation.
The study from September 20, 2019, examined the safety and pain-relieving effects of Tectona grandis (teak) methanolic seed extract in Swiss albino mice. The extract was deemed safe at a dose of 1000 mg/kg and showed significant analgesic effects at 200-250 mg/kg body weight, as evidenced by reduced pain response in acetic acid-induced writhing, tail flick, and tail immersion tests. The pain-relieving properties were likely due to bioactive compounds such as flavonoids, xanthones, and glycosides found in the extract. However, the number of mice used in the study was not mentioned in the document.
