Pharmacological Interventions for Treating Chronic Prostatitis/Chronic Pelvic Pain Syndrome

October 2019 in “ Cochrane library ”

Juan Víctor Ariel Franco, Tarek Turk, Jae Hung Jung … Valeria Vietto

5-alpha reductase inhibitors botulinum toxin A Botox

Studysummary This study found low- to very low-quality evidence suggesting that several pharmacological treatments, including alpha blockers and antibiotics, may reduce prostatitis symptoms without significantly increasing adverse events in the short term, although more rigorous trials are needed.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

Read the full study on cochranelibrary.com →

PubMed
DOI

Discuss this study in the Community →

Research cited in this study 4

Pharmacological Interventions for Treating Chronic Prostatitis/Chronic Pelvic Pain Syndrome Cochrane library · 2019
A Randomized Placebo-Controlled Multicenter Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis) PubMed · 2004
A Prospective, 1-Year Trial Using Saw Palmetto Versus Finasteride in the Treatment of Category III Prostatitis/Chronic Pelvic Pain Syndrome The Journal of Urology · 2004
Effects of Finasteride in Patients with Inflammatory Chronic Pelvic Pain Syndrome: A Double-Blind, Placebo-Controlled, Pilot Study Urology · 1999

Similar research 5

Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome International Journal of Antimicrobial Agents · 2008
Chronic Prostatitis And Chronic Pelvic Pain In Men: Aetiology, Diagnosis And Management Journal of the European Academy of Dermatology and Venereology · 2002
Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia Current pharmaceutical design · 2006
Most Recent Findings of Curative Drugs for Lower Urinary Tract Symptoms in Clinical Practice Nihon Yakuri Gakkai nenkai yoshishu · 2019
Pharmacological Therapy of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms: An Overview for the Practicing Clinician BJU international · 2004

Related Community Posts Join

6 / 1000+ results

community Using botox more effective than finasteride - and an argument against FUT

8 upvotes 6 years ago

Botox injections may be more effective than finasteride for hair growth by reducing scalp tension. The discussion also suggests choosing FUE over FUT due to potential loss of scalp elasticity with FUT.

community Looking for more info about Botox for hair loss

4 upvotes 5 years ago

Botox may help with hair loss by reducing muscle tension and inflammation, potentially lowering DHT levels. Regular sessions might be needed, and it could also help with migraines.

community Any updates on the botox in the scalp muscles treatment?

6 upvotes 1 year ago

Botox in scalp muscles is being discussed as a potential hair loss treatment. Minoxidil, finasteride, and RU58841 are also mentioned as treatments.

community Scalp tension, massage therapy, and Botox! Let’s talk about it!

1 upvotes 1 month ago

The conversation discusses using adjunct therapies like scalp massage and Botox to enhance the effects of DHT inhibitors for hair loss. It also mentions using GHK-cu, finasteride, keto shampoo, and a natural topical DHT-reducing serum for hair regrowth and reduced shedding.

community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 2 years ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle

1 upvotes 1 year ago

The conversation discusses the need for a localized 5-alpha reductase inhibitor that only affects the scalp without systemic side effects, similar to pyrilutamide's approach. Current treatments like topical liposomal finasteride and dutasteride are mentioned, but concerns about their systemic effects and lack of research are highlighted.