Pharmacological Interventions for Treating Chronic Prostatitis/Chronic Pelvic Pain Syndrome

The study assessed the effects of various pharmacological therapies for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in 9119 men across 99 studies. It found low- to very low-quality evidence that alpha blockers, antibiotics, 5-alpha reductase inhibitors, anti-inflammatories, phytotherapy, intraprostatic botulinum toxin A injection, and traditional Chinese medicine may reduce prostatitis symptoms without increasing adverse events in the short term, except for alpha blockers which may cause mild adverse events. There was limited evidence on the impact of these treatments on sexual dysfunction, quality of life, or anxiety and depression. Future trials should improve methodological reporting and include comprehensive assessments of patient-important outcomes and adverse events.