research Sulfation of Minoxidil by Human Liver Phenol Sulfotransferase
Minoxidil activates hair growth by being sulfated by P-PST in the human liver.
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research Cloning of the Human Phenol Sulfotransferase Gene Family: Three Genes Implicated in the Metabolism of Catecholamines, Thyroid Hormones, and Drugs
Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.
research Phenolsulphotransferase: Localization in Kidney During Human Embryonic and Fetal Development
The enzyme PST is found in developing human kidneys and helps with detoxification and development.
research Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles
Minoxidil works in liver and outer hair root sheath for hair growth.
research Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases
Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.
research Minoxidil Sulfation in the Hair Follicle
Minoxidil helps hair growth by activating enzymes in hair follicles.
research Purification and Characterization of Rat Liver Minoxidil Sulphotransferase
Enzyme purified and characterized for minoxidil sulphation in rat liver.
research Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil
Minoxidil needs activation to work, and minoxidil sulfate helps with hair growth and blood pressure.
research Sulphation Catalyzed by the Human Cytosolic Sulphotransferases: Chemical Defense or Molecular Terrorism?
Human enzymes can detoxify harmful substances but might also increase their cancer risk.
research Acne-Associated Syndromes
Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.
research The Importance of Basonuclin 2 in Adult Mice and Its Relation to Basonuclin 1
Basonuclin 2 is vital for the development of facial bones, hair follicles, and male germ cells in adult mice, and its absence can lead to dwarfism and abnormal follicles.
research Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner
Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.
research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction
STAT5 activation is crucial for starting the hair growth phase.
research Novel Missense Mutation in the P-Box of Androgen Receptor in a Patient with Androgen Insensitivity Syndrome
A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.
research Identification of a Novel Heterozygous Mutation in the First Japanese Case of Marie Unna Hereditary Hypotrichosis
Researchers found a new genetic mutation causing a rare hair loss condition in the first Japanese child studied.
research Acne Vulgaris
Acne vulgaris is a common skin condition that can cause low self-esteem and depression, and early treatment is important to prevent scarring.
research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia
People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
research Conditional Ablation of JAK-STAT5 Signaling Induces Anagen Hair Growth
Blocking JAK-STAT5 signaling in mice leads to hair growth.
research Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis Through STAT3 Signal Pathway in Glioma Cells
Saw palmetto extract may help treat brain tumors by blocking a specific growth signal and blood vessel formation.
research Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis
The stiffness of a wound affects hair growth during healing, with less stiff areas growing more hair.
research Novel Approach to Treating Androgenetic Alopecia in Females With Photobiomodulation (Low-Level Laser Therapy)
Low-level laser therapy effectively treats female hair loss, increasing hair count by 51%.
research The Growth of Human Scalp Hair in Females Using Visible Red Light Laser and LED Sources
Red light therapy is safe and effectively increases hair growth in women with hair loss.
research What Causes Hidradenitis Suppurativa?—15 Years After
Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.
research Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia
The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
research Understanding Cellular and Molecular Responses in the Treatment of Pediatric Lymphatic Anomalies
Sirolimus and propranolol may reduce abnormal cell growth and improve lymphatic malformations in children.
research Signal Transducer and Activator of Transcription 5B Deficiency Due to a Novel Missense Mutation in the Coiled-Coil Domain
A boy's growth and immune problems were caused by a new mutation in the STAT5B gene.
research Modified Conchal Cartilage Sandwich Graft Method for Repair of Split Earlobe
A new earlobe repair method using cartilage grafts showed high satisfaction and no re-splitting.
research The Mouse Hairy Ears Mutation Exhibits an Extended Growth (Anagen) Phase in Hair Follicles and Altered Hoxc Gene Expression in the Ears
The mouse hairy ears mutation causes longer ear hair due to changes in gene expression.
research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts
Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.
research Androgenetic Alopecia: An Update
Two drugs, finasteride and minoxidil, are approved for hair loss treatment, but new therapies are being developed.