8 citations
,
December 2015 in “PubMed” In this study, petroleum ether extracts of Phyllanthus niruri promoted hair regrowth in testosterone-induced alopecia in rats by inhibiting the 5α-reductase enzyme.
April 2019 in “Majalah Obat Tradisional” This study found that adding menthol to Phyllanthus niruri ethanol extract gel enhanced hair growth and thickness in rats.
2 citations
,
April 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that lotion containing ethanolic extract of Phyllanthus niruri and 1% menthol enhanced hair growth in white Wistar rats more than a formula without menthol, although not significantly.
January 2018 in “International journal for pharmaceutical research scholars” In this study, topical application of tonic preparations containing 5% ethanol extract of Phyllanthus niruri to shaved mice showed potential as a hair growth enhancer, as indicated by observations of increased hair length and weight over a 21-day period.
30 citations
,
January 2016 in “BioMed Research International” This study identified corilagin as a major antitumor component in Phyllanthus niruri, with broad-spectrum activity against cancer cells and high content in Dimocarpus longan.
This study found that adding menthol to Phyllanthus niruri ethanol extract gel enhanced hair growth and thickness in rats compared to the gel without menthol.
2 citations
,
April 2019 in “Pharmaceutical sciences and research” This study found that lotion containing ethanolic extract of Phyllanthus niruri promoted hair growth in rats, with the addition of 1% menthol enhancing this effect compared to the extract alone.
33 citations
,
May 2013 in “Andrologia” This study identified several herbs, including Ganoderma lucidum and Urtica dioica, that showed promising 5α-reductase inhibitory activity suggesting potential use in managing androgenic disorders.
1 citations
,
May 2017 in “InTech eBooks” This study suggests that while complementary and alternative treatments for hair loss are becoming more popular, their effectiveness and mechanisms remain largely unverified.
16 citations
,
July 2020 in “Advances in Traditional Medicine” This study found that the combined ethanolic extract ethosome formulation of Phyllanthus niruri, Zingiber officianale, and Croton tiglium Linné showed better safety and less cytotoxicity for hair growth promotion compared to the petroleum ether formulations.
5 citations
,
May 2025 in “Scientific Reports” This study found that extracts from Indian gooseberry leaves showed strong antimalarial activity against Plasmodium falciparum, with low cytotoxicity, suggesting potential for developing new antimalarial drugs.
December 2024 in “Tropical Journal of Natural Product Research” This study observed that CTUMP's Herb shampoo significantly improved hair growth and density in mice compared to a saline solution, though it was less effective than minoxidil in promoting follicle development.
January 2020 in “Elsevier eBooks” This chapter provides an overview of phytochemicals with properties to combat alopecia and discusses the potential of flavonoids, found in several herbs, as a safer alternative to synthetic hair loss treatments due to their long-term skin compatibility.
233 citations
,
February 2018 in “Polymers” This review examines the roles and benefits of chitosan in cosmetics and oral hygiene, highlighting its potential in the cosmeceutical market, but it reports no new results.
June 2023 in “MPI (Media Pharmaceutica Indonesiana)” This systematic literature review identified kale leaf hair tonic (Ipomoea aquatica Forsk.) at 5% concentration as an effective herbal cosmeceutical preparation for enhancing hair growth, showing an average increase in hair length over 21 days, while meeting established pharmaceutical standards.
September 2025 in “Jurnal Ilmu Kedokteran dan Kesehatan Indonesia” The study found that a pomade containing bay leaf extract significantly promoted hair growth in New Zealand White rabbits, with the 30% extract formula demonstrating the highest growth compared to lower concentrations and a control without extract.
January 2025 in “International Journal of Veterinary Science” In this animal study, hibiscus leaf simplicia ointment was found to protect red blood cell levels and promote better hair growth in UV-exposed rats, though it did not maintain normal skin histology; the ointment showed no significant acute dermal toxicity.
February 2026 in “Journal of Sylva Indonesiana” This study found that the heartwood extract of Avicennia marina demonstrated strong antioxidant activity, with an IC50 value of 61.50 µg/mL, suggesting potential for development into supplements or topical applications targeting degenerative diseases related to oxidative stress.
November 2024 in “International Journal of Agricultural Invention” This review highlights the therapeutic properties and nutritional value of amla (Phyllanthus emblica), noting its high vitamin C content and diverse pharmacological activities, including antidiabetic and antioxidant effects, as evidenced in traditional medicine practices.
December 2023 in “International Journal of Science and Research (IJSR)” This review article reports that many herbal drugs show potential for treating alopecia effectively and with fewer side effects compared to synthetic drugs, addressing a common issue among urban residents due to stress and environmental factors.
112 citations
,
May 2019 in “Pharmacological Research” This review discusses the isolation, structure, and bioactivity of lignans and neolignans from 2016 to mid-2018, reporting no new clinical results but highlighting their potential protective properties against diseases such as cancer and neurodegeneration.
4 citations
,
March 2020 in “Journal of Cosmetic Dermatology” This study found that Plumbago zeylanica extract and its component plumbagin may help prevent androgenetic alopecia by promoting dermal papilla cell growth and reducing SRD5A2 expression.
1 citations
,
August 2020 in “Food Research” This review discusses management strategies for androgenic alopecia using plant derivatives and highlights the need for prolonged efficacy but reports no new clinical findings.
139 citations
,
October 1999 in “Environmental Health Perspectives” This article reviews the scientific exploration of Ayurvedic medicinal plants and discusses their modern applications, such as a drug developed from Commiphora wightti for lipid disorders, without reporting new clinical findings.
27 citations
,
February 2017 in “Biomedicine & Pharmacotherapy” This study found that white wax and its extract may promote hair growth in a mouse model of androgenetic alopecia by inhibiting 5α-reductase activity and increasing cell proliferation, with efficacy surpassing finasteride.
17 citations
,
February 2015 in “Phytochemistry Reviews” This review discusses the cosmetic potential of Southeast Asian herbs and highlights the need for more systematic scientific evaluation of their efficacy and safety.
13 citations
,
January 2017 in “Molecules” This study reported that compounds isolated from Alpinia zerumbet significantly promoted hair cell growth and exhibited anticancer activity in cell cultures, suggesting potential as treatments for alopecia and cancer.
11 citations
,
December 2018 in “Assay and Drug Development Technologies” This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.
4 citations
,
May 2014 in “International Journal of Research in Ayurveda and Pharmacy” This study documented the traditional medicinal uses of 60 plant species in Kolli Hills, India, highlighting their importance in the healthcare of the local tribal community.
3 citations
,
August 2013 in “International journal of research in Ayurveda and pharmacy” This study assessed the effects of the poly herbal formulation Hairbac, reporting significant improvements in hair texture, density, and loss among females with diffuse hair fall, with no adverse effects noted.