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    Glossary Organ Size Control

    biological processes regulate growth and final size of organs

    Organ Size Control refers to the biological processes that regulate the growth and final size of organs in an organism. This involves a complex interplay of genetic, molecular, and environmental factors that ensure organs grow to the appropriate size for proper function. For example, in hair follicles, organ size control mechanisms ensure that hair grows to a specific length and thickness, which can be disrupted in conditions like alopecia.

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    1. Roles of Hippo signaling pathway in size control of organ regeneration Development Growth & Differentiation · 2015 · 37 citations
    2. Control of hair growth and follicle size by VEGF-mediated angiogenesis Journal of Clinical Investigation · 2001 · 520 citations
    3. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size Molecular Cell · 2018 · 90 citations
    4. Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration Biomaterials · 2012 · 78 citations
    5. 1434 Epithelially derived MPZL3 negatively regulates murine and human sebaceous gland size and sebocyte proliferation Journal of Investigative Dermatology · 2023
    6. Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration Materials Today Bio · 2021 · 22 citations
    7. Short- and mid-term outcomes of multisystem inflammatory syndrome in children: a longitudinal prospective single-center cohort study Frontiers in Pediatrics · 2023 · 4 citations
    8. The therapeutic promise of apoptosis Science · 2019 · 9 citations
    9. Immunohistochemical assessment of SOX10 and its relation to the immune cellular infiltrate in alopecia areata follicles Journal of the Egyptian Womenʼs Dermatologic Society · 2024
    10. Topical Antiandrogens Archives of Dermatology · 1985 · 11 citations
    11. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function Cell death and disease · 2018 · 74 citations
    12. The Organizer and Beyond Cell · 2001 · 9 citations
    13. Oxidative Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016 · 58 citations
    14. The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size Nature Communications · 2025 · 1 citations
    15. Hair Follicles as Micro-Organs: MicroRNA-Mediated Control of Growth, Cycling, and Fiber Traits Biomolecules · 2026
    16. Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size Steroids · 2009 · 15 citations
    17. Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity Journal of Investigative Dermatology · 1995 · 37 citations
    18. Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis Stem Cell Research & Therapy · 2020 · 5 citations
    19. Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders Asian Journal of Pharmaceutical Sciences · 2022 · 14 citations
    20. Developmental Plasticity of Patterned and Regenerating Oral Organs Current Topics in Developmental Biology · 2015 · 5 citations
    21. Circadian clocks: from stem cells to tissue homeostasis and regeneration EMBO Reports · 2017 · 84 citations
    22. Human hair follicle organ culture: theory, application and perspectives Experimental Dermatology · 2015 · 130 citations
    23. Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne Journal of Dermatology · 2010 · 8 citations
    24. Chapter 23. Therapeutic Control of Androgen Action Annual Reports in Medicinal Chemistry · 1994 · 7 citations
    25. Modulating hair follicle size with <i>Wnt10b/DKK1</i> during hair regeneration Experimental Dermatology · 2014 · 53 citations
    26. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003 · 158 citations
    27. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004 · 131 citations
    28. Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case–Control Study American Journal of Clinical Dermatology · 2015 · 28 citations
    29. Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche. Journal of Investigative Dermatology · 1998 · 10 citations
    30. The promoter of an androgen dependent gene in the hamster flank organ Journal of Dermatological Science · 1997 · 6 citations