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research Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8
This study found that IMT-P8, a novel cell-penetrating peptide, effectively facilitated the dermal delivery of proteins and peptides in mouse skin and cell lines, suggesting potential for topical applications in cosmetics and skin diseases.
research Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures
This study identified diltiazem, a calcium channel blocker for hypertension, as a promising repurposed treatment for influenza, enhancing antiviral efficacy when combined with oseltamivir.
research Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface
This study found that reducing BMP signaling in mouse nipple epithelia, achieved through Noggin overexpression, can convert them into hairy skin with pilosebaceous units.
research Optimization of ultrasound-assisted extraction of bioactive compounds from Carthamus caeruleus L. rhizome: Integrating central composite design, Gaussian process regression, and multi-objective Grey Wolf optimization approaches
In this study, Gaussian process regression models combined with Grey Wolf optimization were used to predict and optimize phenolic and flavonoid content extraction from Carthamus caeruleus L. rhizomes, showing high accuracy and helping improve understanding and extraction processes through a new interactive tool.
research Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia
This study investigated the use of Minoxidil encapsulated in HA-PLGA nanoparticles for alopecia treatment and found that these nanoparticles efficiently delivered the drug to hair follicle cells without significant cytotoxicity, offering a potential transdermal delivery method for various diseases.
research miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation
This study suggests that miRNAs, particularly miR-195-5p, may regulate the loss of hair follicle inductivity in cultured dermal papilla cells by suppressing the Wnt/β-catenin pathway.
research AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
This study found that manipulating AKR1D1 expression in human liver cells effectively regulates glucocorticoid clearance and receptor activation, highlighting its role in liver-specific steroid hormone regulation.
research High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders
In this study, the researchers identified CEP135 as a biomarker linked to poor sarcoma survival and suggested PLK1 as a potential therapeutic target for sarcoma patients with high CEP135 expression.
research Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness
In this study, researchers found that interaction between transcription factor EBF1 and gene WNT10A, influenced by a genetic variant, may play a role in hair shaft formation and anagen shortening in male pattern baldness.
research Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms
In this study, researchers observed that quiescent mouse embryonic fibroblasts showed reduced glycolysis but increased TCA cycle flux and mitochondrial respiration, with these changes linked to metabolic reprogramming involving yes-associated protein inhibition and malate cycle modulation, which supports extracellular matrix protein synthesis.
research Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes
This study suggests that transfection with modified KGF-mRNA enhances keratinocyte reepithelialization in wound therapy by temporarily increasing growth factor expression without affecting nuclear DNA.
research A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing
In this study, researchers developed a new photoactivatable Cre recombinase mouse model, DiLiCre, which allows precise light-induced genetic modifications and cell tracing, demonstrating its effectiveness for advancing biological and biomedical research.
research Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice
In this study, researchers found that specific mutations in iRhom2 in mice lead to skin and hair abnormalities which depend on the presence of the protein ADAM17, suggesting a complex role for iRhom2 in tissue development and potential implications for treating tylosis with oesophageal cancer.
research Polysaccharide, Conjugate, and mRNA-based Vaccines are Immunogenic in Patients with Netherton Syndrome
This study observed that adult Netherton syndrome patients showed a range of normal to diminished immune responses to polysaccharide, conjugate, and mRNA-based vaccines, with responses generally overlapping those of healthy controls, suggesting no consistent B- or T-cell immunodeficiency in this population.
research The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis
In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.
research Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome
In this study, the researchers found that glucocorticoid receptor activation may influence glucose metabolism, with preventive GR antagonist treatment reducing hyperglycemia and restoring glucose tolerance in a PCOS mouse model.
research Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone
This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.
research Proliferative necrotizing otitis externa in two young cats
In this paper, regression of proliferative necrotizing otitis externa lesions in young cats was reported following systemic and topical immunomodulatory therapy.
research TLR3 Activation Stimulates Autophagy Gene Expression in Keratinocytes
This study suggests that autophagy is essential for regulating TLR3-mediated regenerative processes in human keratinocytes.
research Optimizing finasteride chemoprevention
research Optimasi Kombinasi Ramuan Etnomedisin Penumbuh Rambut Nusa Tenggara Timur Menggunakan Orthogonal Stimulus Response Method Pada Kepadatan Rambut Mencit (Mus musculus)
In this study, researchers developed an optimized formulation of a traditional ethnomedicinal recipe from East Nusa Tenggara, which demonstrated strong antioxidant activity and significantly enhanced hair growth in a mouse alopecia model, compared to control groups.
research Optimization of finasteride nano-emulsion preparation by using chemometrics approaches (and/or Box-Behnken design and regresion model)
research Optimasi proses pencampuran krim anti hair loss ekstrak saw palmetto [Serenoa repens] dengan perbandingan suh pencampuran dan kecepatan putar : aplikasi desain faktorial
In this experimental study, mixing temperature and rate were found to significantly influence cream's physical properties, with mixing rate affecting spreadability and temperature affecting viscosity.
research OPTIMASI FORMULA HAIR TONIC MIKROEMULSI BIOTIN (VITAMIN B7) DENGAN METODE FACTORIAL DESIGN
This study concluded that the optimum biotin microemulsion hair tonic composition involves span 80 (20%), tween 80 (9.47%), and PEG 400 (5%), providing favorable viscosity and globule size.
research Optimization of Finasteride Nano-Emulsion Preparation Using Chemometric Approach
This study concluded that the Box-Behnken experimental design effectively optimizes the size of finasteride nano-emulsions by assessing the impact of various experimental factors.
research Optimasi Kombinasi Ramuan Etnomedisin Penumbuh Rambut Nusa Tenggara Timur Menggunakan Orthogonal Stimulus Response Method Pada Ketebalan Rambut Mencit (Mus musculus)
This study concluded that the combination 3 of the Nusa Tenggara Timur Ethnomedicinal Formula shows strong antioxidant activity and significantly increases hair follicle thickness in a chemotherapy-induced alopecia model in mice.
research MOOEW: Inovasi Hair Tonic Gel Eco-Friendly Berbasis Hydroxyproline Limbah Tulang Ikan Tenggiri dengan Ekstrak Chamomile Solusi Alopesia Kucing
This study found that MOOEW Hair Tonic had a Return of Investment of over 100%, indicating significant potential for profitable and sustainable business opportunities.
research Optimasi formula krim hair loss ekstrak saw palmetto [Serenoa repens] dengan humectant gliserol dan sorbital : aplikasi desain faktorial
Saw palmetto cream for hair loss works better with glycerol and sorbitol.
research APLICAÇÃO DE PLANEJAMENTO DE EXPERIMENTOS (DoE) PARA OTIMIZAÇÃO DE MÉTODO ANALÍTICO PARA QUANTIFICAÇÃO DE MINOXIDIL POR CLAE
This study optimized conditions for quantifying minoxidil using high-performance liquid chromatography, establishing specific parameters for mobile phase, flow rate, column temperature, and retention time.