Application of Design of Experiments (DoE) for Optimization of Analytical Method for Quantification of Minoxidil by HPLC

    January 2023 in “ Anais do Congresso Brasileiro Interdisciplinar em Ciência e Tecnologia. ”
    Sandra Barbosa Neder Agostini, Magali Benjamim Araújo, Rudy Bonfílio
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    TLDR Optimizing the method improved minoxidil measurement accuracy and efficiency.
    The document discusses the application of Design of Experiments (DoE) to optimize an analytical method for quantifying minoxidil using High-Performance Liquid Chromatography (HPLC). The study focuses on improving the accuracy and efficiency of minoxidil measurement, which is crucial for its use in treating hair loss. By employing DoE, the researchers were able to systematically evaluate various experimental conditions and identify the optimal parameters for the HPLC method. This approach enhances the reliability of minoxidil quantification, which is essential for quality control in pharmaceutical applications. The study highlights the importance of method optimization in ensuring consistent and precise results in the analysis of active pharmaceutical ingredients.
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