Electrochemical Detector for Liquid Chromatography: Determining Minoxidil in Hair-Growth Pharmaceuticals

July 2018 in “ Current Analytical Chemistry ”

Lai-Hao Wang, Pei-Tung Cheng

minoxidil carbon paste electrodes electrooxidation high-performance liquid chromatography electrochemical detector ultraviolet detector Rogaine HPLC UV detector

TLDR The method effectively detects minoxidil in hair-growth products.

The study investigated the electrochemical behavior of minoxidil using various electrodes and buffers, finding that carbon paste electrodes (CPEs) were the most efficient for electrooxidation. High-performance liquid chromatography with an electrochemical detector (HPLC-ECD) was used to detect minoxidil, showing a linear concentration range from 0.02 to 2.6 mg/L and a detection limit of approximately 20 ng/mL. The results from HPLC-ECD were comparable to those obtained using an ultraviolet detector, validating the method's effectiveness for detecting minoxidil in hair-growth pharmaceuticals.

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Research cited in this study

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Development and Validation of a Procedure for the Determination of Minoxidil in Hair-Regrowth Formulations Using Two Variants of Capillary Zone Electrophoresis

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A method was created in 2005 to identify minoxidil, a hair growth ingredient, in products using two types of capillary zone electrophoresis, and it found that most products had about 2% minoxidil.

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research Topical Minoxidil in the Treatment of Male Pattern Alopecia

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Oral minoxidil helps hair regrowth in 80% of alopecia patients, but only 18% see cosmetic improvement.

research Double-Blind, Placebo-Controlled Evaluation of Topical Minoxidil in Extensive Alopecia Areata

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research Dose-Response Study of Topical Minoxidil in Male Pattern Baldness

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Lowest effective minoxidil concentration is 1%, but 2% works better for male pattern baldness.

research Electrochemical Studies on Minoxidil and Its Determination in Tablets by Differential-Pulse Polarography

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