Optimization of Biotin Microemulsion Hair Tonic Formula Using Factorial Design Method

March 2023 in “ JIIS (Jurnal Ilmiah Ibnu Sina): ilmu farmasi dan kesehatan ”

Fauziyyah Al Hasanah, Gunawan Pamudji Widodo, Endang Dyah Ikasari

biotin vitamin B7 microemulsion hair tonic span 80 tween 80 PEG 400 viscosity globule size

TLDR The best biotin hair tonic formula has 20% span 80, 9.47% tween 80, and 5% PEG 400.

The research paper discusses the optimization of a biotin microemulsion hair tonic formula to prevent hair loss and promote hair health. The study used a factorial design method to determine the optimal concentration of span 80, tween 80, and PEG 400 in the biotin microemulsion. The optimal formula was found to contain span 80 (20%), tween 80 (9.466%), and PEG 400 (5%), with a predicted viscosity of 46.75 cPs and a globule size of 2.98 µm. The physical quality of the preparation was tested at this optimal formula, and the results were not significantly different from the predictions, with a significance value of >0.05. The optimal formula had a viscosity value of 47.67 cPs and a globule size of 2.4 µm. The study concluded that the optimal biotin microemulsion formula consists of span 80 20%, tween 80 9.47%, and PEG 400 5%.

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