A Doxycycline- and Light-Inducible Cre Recombinase Mouse Model for Optogenetic Genome Editing

    October 2022 in “ Nature Communications
    Miguel Vizoso, Colin E.J. Pritchard, Lorenzo Bombardelli, Bram van den Broek, Paul Krimpenfort, Roderick L. Beijersbergen, Kees Jalink, Jacco van Rheenen
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    Studysummary In this study, researchers developed a new photoactivatable Cre recombinase mouse model, DiLiCre, which allows precise light-induced genetic modifications and cell tracing, demonstrating its effectiveness for advancing biological and biomedical research.
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