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Dogs have varying numbers of touch-sensitive Merkel cells in different skin areas, with most in the oral mucosa and facial skin, unrelated to age, sex, breed, or color.

Nanoemulgel improves delivery and effectiveness of plant-based drugs for various conditions.

Ethosomes can safely and effectively deliver various drugs deep into the skin.

Early and aggressive treatment of scarring alopecia is important to prevent further hair follicle damage.

Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.

Adalimumab helped control a child's severe eye disease when other treatments failed.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Retinoids are effective for skin conditions like severe acne and psoriasis but must be used with caution due to potential side effects and risks during pregnancy.

JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.

The document explains hair biology, the causes of hair loss, and reviews various hair loss treatments.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Higher antigliadin antibodies are linked to more severe alopecia areata, suggesting screening for celiac disease in these patients.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

Microemulsions could improve skin drug delivery but face challenges like complex creation and potential toxicity.

New vitiligo treatments focus on controlling immune damage and restoring skin color.

Early treatment of acne is crucial to prevent scarring and psychological effects.

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

Understanding skin structure and development helps diagnose and treat skin disorders.

An 8-year-old Saudi boy was diagnosed with a rare genetic disorder causing hair loss, skin issues, and light sensitivity.

DHT stops hair regrowth in mice, similar to human hair loss.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.

There may be a connection between Frontal Fibrosing Alopecia and Lichen Planus Pigmentosus, and more research is needed to confirm this.

Certain drugs are effective for skin conditions like psoriasis, vitiligo, and hair loss.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Spironolactone might lower the chance of getting rosacea.

Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.

Nanoemulgel is a better way to deliver drugs through the skin for various conditions.