The Hair Loss Encyclopedia

Assessment of Serum Levels of Antigliadin Antibodies (IgG and IgA) in Patients with Alopecia Areata and Their Relation to Severity of the Disease

July 2023 in “ Al-Azhar Medical Journal ”

A. Mohamed, Hanan M.A. Darwish, Hoda Kamal Al-Sebaay, Sarah Younes El-Aziz

alopecia areata antigliadin antibodies IgA IgG serological screening celiac disease AA

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TLDR Higher antigliadin antibodies are linked to more severe alopecia areata, suggesting screening for celiac disease in these patients.

This study assessed serum levels of antigliadin antibodies (IgA and IgG) in 30 patients with alopecia areata (AA) compared to 30 healthy controls. Results showed that antigliadin IgA was positive in 26.7% of AA patients with severe disease, while IgG was positive in all AA patients and 6.7% of controls. There was a significant difference in IgA and IgG levels between patients and controls, with higher values in patients. The study concluded a strong association between antigliadin antibodies and AA severity, recommending serological screening for celiac disease in AA patients due to the high sensitivity and specificity of these antibodies.

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Research cited in this study

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Alopecia Areata: A Long-Term Follow-Up Study of 104 Patients

research Alopecia Areata: A Long-Term Follow-Up Study of 104 Patients

29 citations, March 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Older age at onset of alopecia areata leads to less severe and shorter episodes, with most patients experiencing significant hair regrowth.

research Nail Changes in Alopecia Areata: An Update and Review

45 citations, January 2018 in “International Journal of Dermatology”

Nail problems are common in people with alopecia areata, often leading to cosmetic and functional issues, but more research is needed for treatment guidelines.

Late-Onset Alopecia Areata: A Retrospective Cohort Study

research Late-Onset Alopecia Areata: A Retrospective Cohort Study

7 citations, January 2017 in “Dermatology”

People who get alopecia areata after age 50 usually have mild symptoms, high chances of hair regrowth, and often have other health conditions.

research Alopecia Areata: What’s New in Epidemiology, Pathogenesis, Diagnosis, and Therapeutic Options?

56 citations, October 2016 in “Journal of dermatological science”

New insights into the causes and treatments for the autoimmune hair loss condition Alopecia areata have been made.

Epidemiology and Burden of Alopecia Areata: A Systematic Review

research Epidemiology and Burden of Alopecia Areata: A Systematic Review

144 citations, July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

research Prevalence and Treatment of Alopecia Areata in Taif Area, KSA

5 citations, January 2015 in “Saudi journal for health sciences”

Alopecia areata in Taif is common, mainly immune-related, and best treated with topical corticosteroids and vitamins.

research Alopecia Areata in the Elderly: A 10-Year Retrospective Study

9 citations, January 2015 in “Annals of dermatology/Annals of Dermatology”

Alopecia areata in elderly people is usually mild and responds well to treatment.

research Can the Hair Follicle Become a Model for Studying Selected Aspects of Human Ocular Immune Privilege?

21 citations, June 2011 in “Investigative Ophthalmology & Visual Science”

Hair follicles could help develop eye treatments by studying immune responses.

research Investigative Guidelines for Alopecia Areata

66 citations, May 2011 in “Dermatologic therapy”

Guidelines help design better trials to compare alopecia areata treatments.

Related Community Posts Join

6 / 1000+ results

community Alopecia Areata Question

in Treatment 2 upvotes 3 years ago

A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

community mbp alopecia areata or vitamin deficiency

in Chat 5 months ago

A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

community Olumiant alternative for Alopecia Areata?

in Treatment 1 upvotes 1 year ago

A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

community Covid (likely) induced alopecia areata - now 2nd round of Covid, what can I expect?

in Treatment 1 upvotes 1 year ago

After experiencing hair loss due to alopecia areata following COVID-19 vaccination and infection, the individual saw improvement with steroid treatments and Olumiant. They paused Olumiant during a second COVID-19 infection and expressed concern about potential hair loss flare-ups.

community Onion Juice - An effective topical treatment for Alopecia Areata 🧬

in Treatment 1 year ago

Onion juice, when applied topically, is an effective treatment for Alopecia Areata, showing significant hair regrowth in both males and females. The study suggests it could be interesting to test its effectiveness on Androgenic Alopecia.

community Nearly 40% of Adults with Alopecia Areata Taking OLUMIANT® 4-mg Saw at Least 80% Scalp Hair Coverage at 52 Weeks

in Research/Science 6 upvotes 2 years ago

Nearly 40% of adults with alopecia areata achieved at least 80% scalp hair coverage after 52 weeks of taking OLUMIANT® 4-mg. The conversation distinguishes this success from androgenetic alopecia, which is a different type of hair loss.

Related Research

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Serum Zinc Concentration in Patients With Alopecia Areata

research Serum Zinc Concentration in Patients With Alopecia Areata

October 2023 in “Acta dermato-venereologica (Print)”

People with severe hair loss have lower zinc levels in their blood.