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DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

The glucocorticoid receptor helps protect skin from tumors and other issues.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Vitamin D receptor knockout mice have significant motor impairments but no cognitive deficits.

Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

RORA plays a key role in controlling seasonal hair molting by affecting hair follicle cell activity.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

A genetic variant in the androgen receptor gene increases heart disease risk in women but not in men.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Androgen self-administration might be controlled by membrane receptors, not nuclear ones.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

Vitamin D Receptor is crucial for hair follicle shrinkage and cell death, affecting hair growth.

A new treatment called SAMiRNA-AR68 increases hair count in people with hair loss, showing similar results to existing treatments but without side effects.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

MR antagonists may improve skin health and wound healing, especially in aging.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.