Gender Specificity of a Genetic Variant of Androgen Receptor and Risk of Coronary Artery Disease

The document summarizes a study that examined the relationship between the G1733A polymorphism in the androgen receptor gene and the risk of premature coronary artery disease in a Greek population. The study included 460 subjects, with 250 CAD patients and 210 healthy controls. It found that the A allele of the G1733A polymorphism was significantly associated with an increased risk for premature CAD in women, but not in men. The study suggests that this polymorphism could serve as a genetic marker for assessing CAD risk in women within the Caucasian Greek population, but further research is needed to clarify the underlying mechanisms.