10 citations
,
May 2021 in “Stem Cell Research & Therapy” In this study, subcutaneous injection of bone marrow mesenchymal stem cells in burned rats significantly improved wound healing by reducing inflammation, scar formation, and wound size, and restoring normal skin structures.
10 citations
,
January 1985 in “PubMed” This study found that electron and proton microprobe analysis can reveal differences in element distribution within human hair and epidermis, although no significant water content differences were noted between atopic eczema and normal skin.
2 citations
,
August 2017 in “Experimental Dermatology” This study developed a new melanocyte cultivation medium without chemical mitogens, melanogenesis enhancers, or bovine products, demonstrating successful proliferation and melanotic differentiation of human melanocytes from hair follicles.
1 citations
,
December 2015 in “The Egyptian Journal of Histology” This study found that experimentally induced hypothyroidism in rats is associated with impaired skin structure, but topical application of triiodothyronine (T3) improved these changes to resemble normal skin.
This study found that lysine carboxymethyl cysteinate helps protect the epidermis from UVB-induced damage by activating autophagy and restoring cornification processes in a skin model.
January 2025 in “International Journal of Molecular Sciences” This study showed that vitamin D receptor gene-deficient rats exhibit hair loss and skin abnormalities due to differences in gene and protein expression patterns, while ligand-independent VDR action is crucial for normal hair cycle maintenance and skin formation.
This study demonstrated that a ligand-independent action of the vitamin D receptor significantly affects keratinocyte behavior in hair follicles and skin, pointing to its crucial role in maintaining normal hair and skin structures in rats.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study applied a new RGB trichrome stain to human skin samples, revealing distinct structural staining in normal tissues and potential proteoglycan-rich zones in hair follicles.
April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers found that in growing skin tissue, epidermal wound healing occurs at the expense of normal skin development, as it impairs hair follicle growth and does not activate tissue morphogenesis genes.
June 2015 in “OhioLink ETD Center (Ohio Library and Information Network)” This study found that acute UVB exposure in mice increases the synthesis of retinoic acid in the epidermis, which is necessary for normal repair from UVB light.
7 citations
,
October 2024 in “Cells” The researchers reported that autophagy, a lysosome-dependent degradation mechanism, plays a significant role in the cellular remodeling of keratinocyte differentiation in the skin, affecting the properties of the differentiation products by altering cellular components during this process.
139 citations
,
August 2006 in “Molecular and Cellular Biology” This study found that Rac1 is crucial for maintaining the integrity of hair follicle structure but is not needed for skin epidermis maintenance in mice.
January 2012 in “ScholarlyCommons (University of Pennsylvania)” This study found that miRNA biogenesis, facilitated by Dicer and Drosha, is crucial for adult hair follicles' growth and regeneration, highlighting their multiple roles during the hair follicle growth cycle.
56 citations
,
November 2003 in “Journal of Investigative Dermatology” This study identified altered expression of MMP-19 in the skin's epidermal layers during diseases like psoriasis and eczema, implying a role in disease processes.
1 citations
,
January 2023 in “BMC Women's Health” This study reported a 3.86% prevalence of PCOS among tenth-grade schoolgirls in Guangzhou, with higher rates observed in obese girls compared to their lean counterparts.
31 citations
,
March 2016 in “Journal of Investigative Dermatology” AKR1B10 enzyme may cause keloid scars and could be a treatment target.
April 2017 in “Journal of Investigative Dermatology” This study demonstrated that mitochondrial function in keratinocytes is crucial for maintaining skin homeostasis and hair follicle development, as its impairment led to disrupted hair morphogenesis and early death in mice.
17 citations
,
November 2000 in “Journal of Investigative Dermatology” ZPK helps skin cells mature and may affect skin health.
January 2014 in “Durham e-Theses (Durham University)” In this study, the activation of Notch1 signaling in keratinocytes was found to play a key role in recruiting immune cells and facilitating skin repair after injury.
163 citations
,
October 2001 in “EMBO journal” This study found that endogenous activin plays a crucial role in wound healing and scar formation, as its inhibition led to delayed wound healing and reduced scar size in transgenic mice.
5 citations
,
October 2013 in “Experimental Dermatology” This study observed that putrescine and HR form a negative feedback mechanism affecting hair cycling, indicating a significant connection between HR, polyamines, and hair growth regulation.
30 citations
,
January 2013 in “International Journal of Trichology” This study found that in Jordanian children, tinea capitis, alopecia areata, and telogen effluvium were the most common causes of hair loss, with nutritional deficiencies such as iron and zinc deficiency also noted as significant factors.
September 2018 in “CRC Press eBooks” This review explores the trichoscopic features of dark scalp, particularly the brown honeycomb pigment network, and its variations in different types of alopecia, but it presents no new clinical findings.
105 citations
,
February 2010 in “Endocrinology” This study found that normal human epidermis expresses TSH and may be an indirect target of TSH signaling, with expression regulated by endocrine controls of the hypothalamic-pituitary-thyroid axis.
40 citations
,
April 1995 in “Journal of Cutaneous Pathology” This study found that androgen receptor expression varied across different types of skin appendage tumors, with specific expression patterns noted in sebaceous and sweat gland tumors but absent in hair follicle tumors.
143 citations
,
September 2008 in “Experimental gerontology” This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
18 citations
,
September 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that vitamin D-upregulated protein 1 (VDUP1) might play a unique role in regulating the differentiation of epidermal cells.
66 citations
,
December 2014 in “Nature Communications” Fibroblasts can be turned into melanocytes for potential skin treatments.
1 citations
,
September 2021 in “Journal of Cosmetic Dermatology” This study demonstrated that B-mode ultrasound and shear-wave elastography could differentiate individuals at risk of developing androgenetic alopecia from healthy individuals by assessing cranial subcutaneous tissue thickness and epidermis-dermis stiffness.
January 2005 in “中华医学杂志:英文版” This study found that residual sweat glands in hypertrophic scar tissues may regenerate from adult epidermal stem cells or residual glands after burn injury.