Recent Advances in X-Ray Microanalysis in Dermatology

    January 1985 in “ PubMed ”
    B Forslind, T.G. Grundin, Magnus Lindberg, Godfried M. Roomans, Y. Werner
    TLDR Trace elements like calcium, iron, and zinc are unevenly distributed in hair, while sulfur is even, and increased phosphorus and potassium levels are linked to skin reactions.
    The document discussed the use of electron microprobe and proton microprobe X-ray analysis in dermatological research. It highlighted that trace elements like calcium, iron, and zinc were non-homogeneously distributed in human hair, unlike sulfur. In the epidermis, a gradient of sodium, phosphorus, and potassium was observed, which was less steep in freeze-substituted human skin due to decreased water content. Proton microprobe analysis was used to study nickel or chromate ion exposure in human epidermis. No significant differences in water content were found between the stratum corneum of patients with atopic eczema and normal skin. Increased levels of phosphorus and potassium were associated with proliferative reactions in the epidermis, as seen in guinea-pig skin exposed to sodium lauryl sulfate and in psoriasis plaques.
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