The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease

    March 2016 in “ Journal of Investigative Dermatology ”
    Natalie Jumper, Tom Hodgkinson, Guyan Arscott … Ardeshir Bayat
    Studysummary AKR1B10 enzyme may cause keloid scars and could be a treatment target.
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    Research cited in this study 8

    1. Functional Histopathology of Keloid Disease PubMed · 2015
    2. Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing British Journal of Dermatology · 2015
    3. Epithelial–Mesenchymal Transition in Keloid Tissues and TGF-β1–Induced Hair Follicle Outer Root Sheath Keratinocytes Wound repair and regeneration · 2015
    4. A Novel Control of Human Keratin Expression: Cannabinoid Receptor 1-Mediated Signaling Down-Regulates the Expression of Keratins K6 and K16 in Human Keratinocytes In Vitro and In Situ PeerJ · 2013
    5. Endogenous Retinoids in the Pathogenesis of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    6. Tgm2/Gh, Gbx1 and TGF-Beta Are Involved in Retinoic Acid-Induced Transdifferentiation from Epidermis to Mucosal Epithelium The International Journal of Developmental Biology · 2011
    7. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    8. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005