Overcoming the Low Bioavailability of Apigenin: Therapeutic Efficacy for Androgenetic Alopecia Through Topical Administration

    November 2025 in “ Food Science & Nutrition ”
    Yanxi PENG, Huan Zhou, Yiqing Sun, Dane Huang, Chao Zhao
    TLDR Apigenin may effectively promote hair growth for androgenetic alopecia when applied topically.
    This study explores the use of apigenin, a compound found in foods like parsley and chamomile, for treating androgenetic alopecia (AGA) through topical administration to address its low bioavailability. In a 28-day trial with testosterone-induced AGA mice, apigenin's effectiveness in promoting hair growth was comparable to minoxidil and normal groups, outperforming the model group. The study suggests that apigenin may enhance hair growth via the Wnt signaling pathway, with CDK5 identified as a potential target. These findings support the potential of apigenin as a topical treatment for AGA.
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