December 2025 in “Journal of Nanobiotechnology” This study introduced a novel microneedle-based system for androgenetic alopecia treatment, which delivered Ginsenoside Compound K and S-nitrosoglutathione to enhance hair regeneration by improving the hair follicle microenvironment and promoting follicular cell proliferation.
3 citations
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July 2021 in “Life science alliance” This study observed that disrupting the Pnkp gene in adult mice resulted in a premature aging-like phenotype, suggesting PNKP's vital role in maintaining normal growth and survival of certain progenitor cell populations.
1 citations
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May 2025 in “International Journal of Applied Pharmaceutics” This study formulated a nanogel with Bangkal bark extract that showed moderate antibacterial activity against Propionibacterium acnes, with the F3 formulation (8% extract) achieving the highest inhibition zone of 8 mm, suggesting potential as a natural acne treatment.
13 citations
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August 1985 in “The Journal of Dermatology” This study identified a monoclonal antibody, HKN-2, that recognizes specific cells in human skin and may indicate a common antigenic determinant between hair and other skin epithelial tissues.
June 2021 in “The Journal of Family Practice” This case report discusses a 69-year-old woman with alopecia areata who presented with a growing lesion on her hand, raising diagnostic considerations during her appointment for scalp steroid injections.
December 2023 in “Curēus” In this case study, researchers reported the first instance of keratoacanthoma on the scalp of an elderly patient in Saudi Arabia, highlighting the diagnostic challenge due to its resemblance to squamous cell carcinoma.
27 citations
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June 2017 in “International Journal of Dermatology” This study found that acne keloidalis nuchae was associated with pseudofolliculitis barbae, chronic scalp folliculitis, and aspects of the metabolic syndrome, particularly hypertension, in the examined population.
July 2024 in “Journal of Investigative Dermatology” In these two clinical trials, DS-2325a, a KLK5 inhibitor, was found to be generally safe and well tolerated in healthy volunteers, with mild and non-serious adverse events, suggesting its potential for further development as a treatment for Netherton Syndrome.
14 citations
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November 2015 in “Dermatology” This study observed inflammatory and granulomatous infiltration in alopecic nodules of the scalp and suggested that AANS should be considered in diagnoses of alopecic nodules.
July 2022 in “SKIN The Journal of Cutaneous Medicine” This case report presents the first successful treatment of acne keloidalis nuchae with a combination of halobetasol 0.01% and tazarotene 0.045% lotion.
2 citations
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April 2024 in “Journal of Dermatological Science” This study suggests that the MLKL-targeting inhibitor Necrosulfonamide promotes hair growth and counteracts DHT inhibition by activating Wnt signaling in hair follicle cells, revealing potential avenues for anti-alopecia drug development.
January 2026 in “Journal of Materials Chemistry B” This study concluded that the KNPs@M/G microneedle system offers a promising strategy for treating radiation-induced skin injury by promoting antioxidative, anti-inflammatory, and regenerative effects.
September 2025 in “The health sciences AUS.” This review discusses the efficacy and safety of intralesional triamcinolone acetonide for treating acne keloidalis nuchae, highlighting its significant effectiveness with rare side effects when used properly.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study analyzed blood samples from individuals with alopecia areata and found that NKG2D+ immune cells, particularly memory-like NK cells, may better correlate with disease activity compared to CD8+ cells, though significant variability among individuals complicates these findings.
June 2025 in “British Journal of Dermatology” This review highlights that acne keloidalis nuchae notably affects men with afro-textured hair and results in scarring and hair loss, underscoring the need for improved diagnosis and treatment strategies due to its significant psychosocial impact and high recurrence rates following current therapies.
8 citations
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August 1987 in “The Journal of Dermatology” This study reports that the monoclonal antibody BKN-1 specifically stained basal cell epithelioma cells and certain normal skin structures, indicating a similarity in keratin expression between the tumor and follicular epithelium below the isthmus portion.
6 citations
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April 2016 in “Australasian journal of dermatology” Renal transplant patients on tacrolimus and sirolimus may develop acne keloidalis nuchae.
15 citations
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December 2016 in “Advanced Pharmaceutical Bulletin” This study found that N-acetyl-glucosamine-loaded nanostructured lipid carriers showed promise for skin lightening in healthy volunteers by reducing melanin distribution.
66 citations
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October 2003 in “Dermatologic clinics” Excision and laser techniques can effectively treat acne keloidalis nuchae.
October 2024 in “Small Methods” This study found that dissolving microneedles loaded with platinum nanozymes induced faster hair growth in an androgenetic alopecia model than daily minoxidil applications, with no significant safety concerns.
6 citations
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December 2011 in “Clinical and Experimental Dermatology” A woman developed rare, unexplained curly hair on her scalp and eyelashes.
9 citations
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June 2019 in “JAAD case reports” This report discusses laser hair removal for acne keloidalis nuchae, noting generally favorable outcomes but variability in lesion responsiveness and a need for standardized assessment criteria; it reports no new results.
27 citations
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April 2018 in “Journal of autoimmunity” In this study, iNKT10 cells were found to play a significant role in preventing and treating alopecia areata in a humanized mouse model, suggesting these cells could have potential in managing related autoimmune disorders.
28 citations
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February 2014 in “Journal of Cutaneous Pathology” In this study, researchers observed that keratoacanthoma exhibits dynamic follicular differentiation throughout its stages, with changes in specific keratin expressions, and regressed lesions showing epidermal rather than follicular characteristics.
This study found that Nourkrin significantly improved hair growth in individuals with hair loss and was well-tolerated, suggesting it may be a viable alternative to pharmacotherapy for androgenetic alopecia.
2 citations
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January 2025 in “Pharmaceutical Research” This article reviews the possible therapeutic activities of Angelica gigas Nakai root extracts and their components, noting their potential effects on neuro-cognitive, metabolic, and other health conditions, and reports no new clinical results.
In this case report, combination therapy with topical tretinoin, topical and intralesional steroids, and systemic doxycycline showed improvement in AKN lesions for a 19-year-old man, with notable reductions in lesion size and number observed by the second week.
7 citations
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May 2022 in “Cancers” This study found that UC.145 influences DKK1 methylation and Wnt signaling in gastric cancer, with implications for patient survival and its potential as a predictive biomarker.
1 citations
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August 2023 in “Clinical, Cosmetic and Investigational Dermatology” In this study, researchers observed that a hidden scalp condition could contribute to acne keloidalis nuchae and potentially other primary cicatricial alopecias, impacting their diagnosis and treatment.
This study reports that a novel ketoconazole-loaded microneedle array significantly enhances drug delivery and retention in the skin, demonstrating improved hair growth in animal models, suggesting a promising treatment for androgenic alopecia that addresses current topical therapies' limitations.