January 2025 in “Journal of Applied Pharmaceutical Science” This study examined the effectiveness of peppermint essential oil formulated into a nanoliposome gel for enhancing hair growth, finding that this preparation increased hair growth in male Sprague Dawley rats without causing irritation, suggesting it may improve delivery of these active ingredients.
January 2003 in “Zhonghua shiyan waike zazhi” This study found that androgen is essential for erectile function in rats, and suggests that its effects may be partly mediated through nitric oxide synthase positive neurons in the medial preoptic area.
1 citations
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January 2019 in “Advances in Medical Sciences” This study found that a combination of azelaic acid, minoxidil, and caffeine significantly reduced skin flap necrosis in rats, likely by increasing nitric oxide content and iNOS expression, compared to individual treatments.
March 2026 in “Critical Care Medicine” In this case study, treatment with methylene blue successfully improved blood pressure in a patient with refractory vasodilatory shock due to massive minoxidil ingestion, highlighting its potential as an adjunctive therapy.
7 citations
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October 2018 in “Dermatology practical & conceptual” This study found that topical oxygen therapy may be a beneficial adjuvant treatment for hair loss, acne, and chronic dermatological conditions, though further research is needed to confirm its effectiveness.
November 2025 in “Discover Pharmaceutical Sciences” In this study, a nanoemulsion containing lavender, peppermint, and rosemary essential oils was developed and shown to promote hair growth in mice at a rate comparable to 2% topical minoxidil, suggesting a promising natural alternative due to its antioxidant and anti-inflammatory effects.
48 citations
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June 1988 in “PubMed” In this study, minoxidil sulfate was found to relax norepinephrine-induced contractions in rabbit mesenteric arteries, possibly by acting as a K+ channel agonist, but it did not relax K+-induced contractions.
21 citations
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January 1999 in “Molecular and Cellular Biochemistry” Niacin deficiency makes rats more sensitive to cancer-causing chemicals.
Anesthetizing walruses is difficult and risky due to their size and sudden health changes.
3 citations
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May 2018 in “Biochemical and Biophysical Research Communications” In this study, researchers found that inhibiting inducible nitric oxide synthase (iNOS) promoted hair growth in diabetic mice, suggesting iNOS-derived nitric oxide contributes to hair loss under diabetic inflammatory conditions.
June 2025 in “ACS Materials Letters” July 2026 in “Journal of the American Academy of Dermatology”
1 citations
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October 1990 in “The Lancet” Using minoxidil for hair growth may cause skin lesions in some people, and taking breaks from nitrate patches for angina might worsen symptoms.
11 citations
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July 2023 in “Applied Nanoscience”
11 citations
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May 1990 in “Journal of Dermatological Science” In this animal study, topical diazoxide treatment led to increased hair thickness and follicle growth in bald stumptailed macaques without causing notable systemic side effects.
7 citations
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July 2022 in “Pharmaceuticals” This study reports that pumpkin seed oil-loaded niosomes significantly decreased hair loss and increased hair growth indicators in vivo, suggesting potential as a natural anti-hair loss therapy.
18 citations
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July 1975 in “Clinical Pharmacology & Therapeutics” Oral minoxidil effectively controls blood pressure quickly and safely.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study developed a dissolvable microneedle system loaded with nanozymes and minoxidil that enhanced hair regeneration in androgenetic alopecia mouse models by improving blood flow, reducing reactive oxygen species, and increasing cell proliferation compared to minoxidil alone.
November 2025 in “Undersea and Hyperbaric Medicine” This case report observed that a patient experienced worsening alopecia and scarring after medical ozone therapy, with subsequent improvement following surgical intervention and systemic hyperbaric oxygenation.
6 citations
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August 2016 in “Journal of microencapsulation” This study suggests that a hair lotion containing methyl myristate loaded in cationic niosomes may effectively accelerate pigmentation in aged C57BL/6 mice compared to free methyl myristate.
12 citations
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December 2018 in “Clinical Ophthalmology” This review summarizes clinical trials and comparative studies showing that latanoprostene bunod 0.024% is effective and safe for reducing intraocular pressure in patients with open-angle glaucoma or ocular hypertension, detailing its mechanism and side effects while considering its therapeutic role.
January 2022 in “Journal of Cutaneous and Aesthetic Surgery” Using truncal anesthesia on the supraorbital nerve reduces pain in hair loss treatments and improves patient comfort.
268 citations
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April 2009 in “International Journal of Pharmaceutics” In this study, niosomal formulations enhanced minoxidil skin accumulation compared to commercial and control solutions, suggesting a potential improvement for topical delivery in hair loss treatment.
This study found that niosomal aminexil was more clinically effective for hair growth than conventional aminexil solutions, and that niosomes facilitated aminexil penetration through rat skin without propylene glycol.
In this study, a nanoemulsion containing Lavender, Peppermint, and Rosemary oils significantly promoted hair growth in C57BL/6 mice, showing effects comparable to 2% minoxidil, following formula optimization and ex vivo skin permeation testing.
3 citations
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September 1989 in “Journal of Investigative Dermatology” This study found that methyl nonanoate and methyl caprate significantly enhanced the skin penetration of minoxidil compared to solutions with other common enhancers like Azone, DMSO, or DEET.
28 citations
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September 2019 in “International Journal of Nanomedicine” This study found that minoxidil nanoparticles increased drug delivery to hair follicles and improved hair growth more effectively in mice than conventional minoxidil formulations.
15 citations
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May 2009 in “Chemical Physics Letters” This study demonstrated that a metric based on rotational echo intensity in 2H magic-angle spinning NMR can derive kinetic information for conformational exchange without complex modelling, achieving activation barriers consistent with prior findings.
July 2023 in “UNESP Institutional Repository (São Paulo State University)” This study found that oral minoxidil increased the growth rates of nails and hair in healthy adult men, with 2.5mg proving more effective for nails than 1mg, and both doses boosting hair growth, without significant adverse effects.
February 2023 in “Clinical Toxicology” This letter to the editor raises concerns about minoxidil, an arterial vasodilator also used for androgenic alopecia, noting that overdose can cause severe side effects such as distributive shock, pulmonary edema, and myocardial ischemia.