Dermatologic Medical Ozone Therapy Complications Treated With Hyperbaric Oxygen

November 2025 in “ Undersea and Hyperbaric Medicine ”

MedStar Georgetown University Hospital, RN Patricia McCray, 3800 Reservoir Road NW, DC 20007 Washington, Kelly Johnson‐Arbor, Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital; 3800 Reservoir Road NW, Washington, DC 20007

medical ozone therapy alopecia hyperbaric oxygen therapy collagen formation tissue vascularity healing

TLDR Medical ozone therapy can cause serious complications, but hyperbaric oxygen therapy can help treat these issues.

Medical ozone therapy, used for conditions like hair growth and collagen formation, can lead to serious complications, as demonstrated in a case involving a 43-year-old woman who experienced worsening alopecia and scarring after ozone injections. Her condition required surgical intervention and a course of 40 hyperbaric oxygen treatments to improve tissue vascularity and healing. The study concludes that despite potential cellular benefits, the clinical risks of medical ozone therapy may outweigh its therapeutic advantages, and hyperbaric oxygenation can be beneficial in managing complications.

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