15 citations
,
February 2013 in “Journal of Clinical Medicine and Research” The researchers reported that both cryotherapy and betamethasone lotion yielded similar improvement rates for alopecia areata patches, without complete recovery observed in any patient.
8 citations
,
February 2022 in “Dermatologic Therapy” This study found that both fractional CO2 laser and cryotherapy were effective and safe treatments for alopecia areata, with the CO2 laser showing somewhat better results.
In this randomized controlled trial at Bolan Medical Complex Hospital, researchers observed that liquid nitrogen cryotherapy increased hair regrowth by 60% in alopecia areata patients, significantly outperforming alternative treatments, which achieved 40% regrowth.
This study found that liquid nitrogen cryotherapy resulted in good responses in 33% of patients with recalcitrant alopecia areata, although nearly 30% showed no response.
This study found that liquid nitrogen cryotherapy significantly improved alopecia areata in 27.4% of treated patients after six weeks, with no association between treatment efficacy and factors like age or gender.
July 2021 in “MVP journal of medical science” This study investigated Liquid Nitrogen Cryotherapy for alopecia areata unresponsive to standard treatments and found that three out of five patients exhibited excellent hair regrowth, with manageable adverse effects like pain and erythema, suggesting potential as an alternative treatment.
7 citations
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June 2018 in “Cryobiology” This study found that freezing nitrogen ethanol composite (FNEC) caused less cryoablative damage to surrounding normal tissue than liquid nitrogen in a mouse model of human bone xenograft transplantation.
April 2023 in “Journal of Investigative Dermatology” This review found that while about 60% of patients with alopecia areata responded to liquid nitrogen cryotherapy in existing studies, no significant efficacy difference was observed compared to intralesional steroid injections, though relapse rates may be lower with cryotherapy.
April 2021 in “Sohag Medical Journal” This research suggests that superficial cryotherapy is a safe and nearly as effective alternative to topical steroids and PUVA therapy for treating alopecia areata, especially in children.
6 citations
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July 2023 in “Journal of Drugs in Dermatology” This narrative review found that cryotherapy resulted in approximately 60% hair regrowth response in alopecia areata patients, with some evidence suggesting lower relapse rates compared to intralesional steroid injection, although no statistically significant difference in efficacy was identified.
15 citations
,
October 2006 in “Journal of the American Academy of Dermatology” This case report describes subcutaneous emphysema in a patient's forearm as a rare complication of liquid nitrogen spray used on hypertrophic actinic keratosis, resolving spontaneously within a day.
1 citations
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February 2002 in “Dermatologic Surgery” A cheap stainless steel container from a retail store can store liquid nitrogen effectively for 8-12 hours, saving money for medical practitioners.
February 2002 in “Dermatologic Surgery” A cheap stainless steel container from a retail store can store liquid nitrogen effectively for 8-12 hours, offering a cost-effective alternative to specialized medical containers.
18 citations
,
April 1989 in “Clinics in Dermatology” This study found that using an argon gas-based system for intralesional cryotherapy significantly reduced keloid scar volume, improved scar quality, and resulted in low recurrence rates after 12 months.
January 2016 in “Springer eBooks” This review discusses the potential of superficial cryotherapy as an effective and safe treatment for alopecia areata in eyebrows, with a proposed mechanism involving improved follicular nutrition, but reports no new clinical results.
July 1988 in “Journal of The American Academy of Dermatology” This article reviews therapeutic advances published between December 1986 and December 1987 but reports no new research findings; readers are advised to consult the original articles before considering new therapies.
5 citations
,
September 2024 in “Journal of Clinical Medicine” This article reviews the pathophysiology of chemotherapy-induced alopecia and reports that scalp cooling can reduce hair loss by 50% in patients with early breast cancer receiving chemotherapy, without compromising survival or increasing scalp metastasis risk.
16 citations
,
October 2016 in “The Journal of Dermatology” In this retrospective study, 60.9% of patients with alopecia areata responded to superficial hypothermic cryotherapy, with effectiveness notably higher when the treatment interval was 2 weeks or less, particularly in early disease stages, and minimal side effects were observed.
1 citations
,
January 2022 in “The Egyptian Journal of Hospital Medicine ” This study found that both superficial cryotherapy and intralesional corticosteroid injections significantly improved hair growth in patients with alopecia areata, with similar efficacy between the two treatments, establishing cryotherapy as a simple and noninvasive treatment option.
11 citations
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August 2016 in “Journal of dermatological treatment” This study evaluated the effects of tip cryotherapy on idiopathic guttate hypomelanosis lesions, finding that 82.3% of treated lesions showed significant improvement after four months compared to only 2% of control lesions, with minimal side effects.
7 citations
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January 2017 in “International Journal of Dermatology” This study found that superficial cryotherapy significantly increased hair density and thickness in treated eyebrows compared to untreated controls after 5 months in patients with alopecia areata.
November 2025 in “The Journal of Medical Sciences” This article reviews the potential and limitations of cryotherapy for alopecia areata in middle-aged patients and highlights the need for further research, without reporting new clinical findings.
December 2024 in “Acta Medica” In this case report, a patient developed facial zona zoster as an unexpected complication following cryotherapy, adding to the list of known adverse effects such as dyspigmentation, scar formation, and hair loss.
3 citations
,
January 2020 in “Acta Dermatovenerologica Alpina Pannonica et Adriatica” Cryotherapy is effective for ingrown toenails, especially in single cases, but has high recurrence in younger and bilateral cases.
January 2026 in “Dermatology Practical & Conceptual” In a systematic review and meta-analysis, the researchers found that intralesional triamcinolone acetonide was more effective than cryotherapy for achieving significant hair regrowth in patients with patchy alopecia areata, although both treatments had distinct safety profiles.
1 citations
,
January 2015 in “Springer eBooks” Chemotherapy can cause skin side effects that affect patients' lives, but they can be managed to avoid interrupting cancer treatment.
January 2025 in “Journal of the Egyptian Womenʼs Dermatologic Society” In this study, both fractional carbon dioxide laser therapy and cryotherapy were found to be effective and safe for treating patchy alopecia areata, showing similar efficacy in improving hair growth compared to untreated control patches.
59 citations
,
December 2016 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses the clinical features and treatment challenges of acne keloidalis nuchae, a form of chronic scarring folliculitis, and reports no new results.
51 citations
,
December 2011 in “The Journal of Dermatology” This review discusses updated treatment guidelines for alopecia areata in Japan, highlighting new options like corticosteroid pulse therapy, but reports no new clinical results.
34 citations
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August 2002 in “British Journal of Dermatology” This study observed that two patients treated with interferon α-2b and ribavirin for chronic hepatitis C experienced complete and reversible straightening of their natural curly hair, which recurred with treatment resumption.