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Glossary Nitric Oxide Synthase

enzyme producing nitric oxide for blood vessel dilation and more

Nitric Oxide Synthase (NOS) is an enzyme responsible for producing nitric oxide, a molecule that plays a crucial role in various physiological processes, including blood vessel dilation, immune response, and neurotransmission. There are three main types of NOS: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS), each serving different functions in the body.

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research 5α-reductase activity in the prostate

237 citations , December 2001 in “Urology”

This review discusses the role of 5α-reductase in prostate development and BPH, and reports no new clinical results; ongoing trials are exploring dual isozyme inhibitors for improved treatment efficacy.

research Administration of dutasteride in animal models of retinitis pigmentosa

December 2022 in “Acta Ophthalmologica”

In this study, dutasteride treatment in retinitis pigmentosa mice increased photoreceptor survival and reduced glial activation, suggesting it may offer a neuroprotective effect.

research The expression of inducible nitric oxide synthase (iNOS) in the testis and epididymis of rats with a dihydrotestosterone (DHT) deficiency

28 citations , January 2009 in “Cellular & Molecular Biology Letters”

This study concluded that finasteride-induced DHT deficiency intensified constitutive iNOS expression in rat testicular and epididymal cells, suggesting a complex regulatory relationship needing further investigation.

research Combination therapy profoundly improved skin flap survival by modulating KATP channels and nitric oxide

1 citations , January 2019 in “Advances in Medical Sciences”

This study found that a combination of azelaic acid, minoxidil, and caffeine significantly reduced skin flap necrosis in rats, likely by increasing nitric oxide content and iNOS expression, compared to individual treatments.

research Nitric Oxide Signal Transduction and Its Role in Skin Sensitization

1 citations , June 2023 in “Biomolecules & therapeutics”

This article reviews the role of nitric oxide in skin health, including its influence on immune responses and potential therapeutic applications for contact dermatitis, but reports no new clinical results.

research Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

10 citations , August 2023 in “Advanced Science”

This review discusses nitric oxide's physiological roles and the development of strategies for delivering it exogenously, without presenting new clinical results.

research iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice

3 citations , May 2018 in “Biochemical and Biophysical Research Communications”

In this study, researchers found that inhibiting inducible nitric oxide synthase (iNOS) promoted hair growth in diabetic mice, suggesting iNOS-derived nitric oxide contributes to hair loss under diabetic inflammatory conditions.

research Baiting Proteins with C₆₀

106 citations , April 2010 in “ACS Nano”

This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.

research Exploring lncRNA-Mediated Mechanisms in Muscle Regulation and Their Implications for Duchenne Muscular Dystrophy

June 2025 in “International Journal of Molecular Sciences”

This review compiles current research on the role of long non-coding RNAs in regulating muscle growth and regeneration processes, particularly their influence on Duchenne muscular dystrophy, and reports no new clinical results.

research Enzymes

March 2008 in “British Journal of Pharmacology”

This guide provides an overview of the complex roles and mechanisms of various receptors and channels in pharmacology but does not report new experimental results.

research Saying no to SARS-CoV-2: the potential of nitric oxide in the treatment of COVID-19 pneumonia

13 citations , September 2023 in “Medical Gas Research”

This review explores the molecular mechanisms and potential roles of nitric oxide in COVID-19 therapy, but provides no new clinical results.

research Protective cardiovascular and renal actions of vitamin D and estrogen

13 citations , December 2012 in “Frontiers in bioscience”

This review discusses the potential role of vitamin D deficiency in cardiovascular and renal diseases and suggests that supplemental vitamin D could benefit cardiovascular outcomes, especially in African American and postmenopausal women; it reports no new clinical findings.

research Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

520 citations , January 2017 in “AIMS biophysics”

This review discusses the effects of photobiomodulation, particularly its potential to reduce inflammation in various conditions, but it does not report new clinical findings.

research The Neurobiology of Sexual Function

393 citations , November 2000 in “Archives of General Psychiatry”

This review discusses the neurobiology of sexual function and reports no new results; the authors cover multiple endocrine and neurotransmitter influences on sexual desire, arousal, and orgasm stages.

research Proposed mechanisms of low-level light therapy in the treatment of androgenetic alopecia

8 citations , October 2020 in “Lasers in Medical Science”

This review suggests that low-level light therapy can promote hair growth in patients with androgenetic alopecia, but more research is needed to standardize treatment parameters and assess long-term safety and efficacy.

research Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition

1 citations , February 2023 in “Plants”

This study reported that rice bran oil from the Thai rice variety BB4CMU showed potential in promoting melanin production and inhibiting steroid 5α-reductase, suggesting a natural option for hair revitalization.

research Low Level Laser and Light Therapy

June 2011 in “CRC Press eBooks”

Low-Level Laser Therapy can stimulate healing and cell function, potentially leading to wider medical use.

research Effects of androgen on extracellular vesicles from endothelial cells in rat penile corpus cavernosum

3 citations , January 2021 in “Andrology”

This study found that low androgen levels in rat penile endothelial cells were associated with a decrease in eNOS-expressing extracellular vesicles and reduced nitric oxide production.

research Ultrasound-responsive hydrogel with ROS scavenging and NO controllable release capabilities for accelerated healing of diabetic wounds

January 2026 in “Materials Today Bio”

This study demonstrated that a multifunctional hydrogel containing Prussian blue nanozymes and an ultrasound-responsive nitric oxide donor improved healing in diabetic wounds by reducing oxidative stress, promoting angiogenesis, and enhancing tissue repair in animal models.

research Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats

4 citations , April 2022 in “Evidence-based Complementary and Alternative Medicine”

This study found that dracorhodin perchlorate improved wound healing in diabetic rats by regulating the TLR4 pathway and related inflammatory factors.

research Neuroimmunomodulation in chronic wounds: an opinion

March 2025 in “Frontiers in Cell and Developmental Biology”

This study reviewed how neuropeptides and cutaneous innervation play crucial roles in the process of wound healing, suggesting they significantly influence inflammation and tissue repair phases.

research Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review

38 citations , January 2023 in “International Journal of Medical Sciences”

This review discusses the potential of repeated low-level red-light therapy to inhibit myopia progression through metabolic effects, highlighting its molecular and cellular impact, but reports no new clinical results.

research Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

4 citations , June 2023 in “Frontiers in Aging”

This scoping review evaluates the connection between hypoxia and declining sex hormonal signaling in middle-aged individuals, proposing a "middle-aging hypovascularity hypoxia hypothesis" as a potential mechanism influencing age-related diseases, with implications for developing strategies to maintain healthspan.

research Regulatory Processes of the Canonical Wnt/β-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair

11 citations , April 2022 in “International Journal of Molecular Sciences”

This review discusses the role of the Wnt/β-catenin pathway in skin wound repair and explores how photobiomodulation may affect chronic wound healing, but it reports no new clinical results.

Role of Neurosteroids in Ischemic Postconditioning-Induced Attenuation of Cerebral Ischemia-Evoked Neuronal Injury and Behavioral Deficits in Mice

research Role of neurosteroids in ischemic postconditioning-induced attenuation of cerebral ischemia-evoked neuronal injury and behavioral deficits in mice

1 citations , January 2015 in “Der pharmacia lettre”

This study found that neurosteroids might play a role in the neuroprotective effects of ischemic postconditioning by reducing brain infarct size and improving motor performance and memory in mice.

research Materials, Syntheses and Biomedical Applications of Nano-Quercetin Formulations: A Comprehensive Literature Review

4 citations , July 2025 in “International Journal of Nanomedicine”

This review explores nano-quercetin formulations to enhance the solubility, stability, and targeted delivery of quercetin, highlighting its potential efficacy in treating cancer, inflammation, metabolic diseases, and tissue regeneration, though challenges in biocompatibility, toxicity, and production remain, per this source.

research Medicinal Chemistry of Drugs with N-Oxide Functionalities

54 citations , March 2024 in “Journal of Medicinal Chemistry”

This article summarizes the properties, synthesis, and biomedical applications of molecules with N-oxide functionalities, emphasizing their growing role in healthcare due to their unique properties, such as water solubility and redox reactivity, crucial for drug targeting and cytotoxicity.

research Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

43 citations , January 2016 in “Oxidative medicine and cellular longevity”

This review discusses the biological effects and mechanisms of THSG in antiaging and related disease treatments but reports no new experimental findings.

research Microcirculation-Promoting Effect of Escin on Cutaneous Tissue via Gsk3β Down-Regulation

1 citations , October 2025 in “Current Issues in Molecular Biology”

This research found that escin, when applied topically, enhances blood flow in human skin and promotes changes in endothelial cell signaling pathways, suggesting potential benefits for improving cutaneous microcirculation.

research Unravelling a novel role for cannabidivarin in the modulation of subventricular zone postnatal neurogenesis

7 citations , October 2023 in “European Journal of Pharmacology”

This study found that Cannabidivarin (CBDV) promotes neuronal differentiation and inhibits oligodendrocyte maturation via TRPV1 modulation, highlighting its potential in neural stem cell research.