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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Gut microbes significantly affect brain steroid levels.

Cocaine impairs male sexual behavior and alters testosterone metabolism in the brain.

Stress and hormones like progesterone can affect absence seizures, but their effects change with different life stages.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

Post-finasteride patients show changes in gut bacteria, possibly causing various symptoms.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

Finasteride reduces sperm count and quality and alters hormone levels in mice.

Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.

5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

Finasteride may cause vitiligo, sexual issues, and depression; better treatments and predicting side effects needed.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.

Hair follicle development in cashmere goats involves dynamic changes in proteins and metabolites, with key roles for oxytocin, MAPK, and Ca2+ pathways.

Men and women have different levels and production of brain steroids, which may affect their risk for certain brain disorders.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.