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Liver transplantation is a viable option for children with propionic acidemia, improving quality of life and diet, but does not remove all risks and long-term brain outcomes are uncertain.

A20 protein is crucial for normal skin and hair development.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

Certain drugs that block specific enzymes can help treat prostate diseases.

South Asian women with PCOS experience more psychological distress and have a poorer quality of life, especially in social relationships, with hirsutism affecting them more than obesity.

Older age, higher BMI, and family history of diabetes increase the risk of gestational diabetes in pregnant women.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Human amniotic membrane helps heal skin wounds faster and with less scarring.

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Fetal cells could improve skin repair with minimal scarring and are a potential ready-to-use solution for tissue engineering.

Some patients with mycosis fungoides or Sézary syndrome experience hair loss, which may be similar to alopecia areata or linked to skin lesions, possibly due to abnormal T cells, and bexarotene can help treat it.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Adrenal disorders can cause lasting brain and behavior issues in children.

Trichoscopy is a useful tool for diagnosing hair disorders without pulling out hair.

Boys with less severe EDA mutations in XLHED have milder symptoms and better sweat and hair production.

Human hair follicle dermal cells can effectively replace other cells in engineered skin.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

BMP2 needs periosteal tissue to help regenerate mouse middle finger bones within a specific time.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

BAF200 is essential for proper heart and coronary artery formation.

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.

Nonclassic congenital adrenal hyperplasia is a genetic disorder causing hormone imbalances, affecting fertility and requiring personalized treatment.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

Isoproterenol helps hair follicle stem cells turn into beating heart muscle cells.

South Asian women with PCOS present with different symptoms compared to White women, influenced by ethnicity, obesity, and age.