Clinical Characteristics of Polycystic Ovary Syndrome: Investigating Differences in White and South Asian Women

    March 2015 in “ Clinical Endocrinology ”
    Hamidreza Mani, Melanie J. Davies, Danielle H. Bodicoat, Miles Levy, Laura J. Gray, Trevor A. Howlett, Kamlesh Khunti
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    TLDR South Asian women with PCOS present with different symptoms compared to White women, influenced by ethnicity, obesity, and age.
    The study analyzed retrospective data from 1,310 women with polycystic ovary syndrome (PCOS) who visited a specialist clinic in Leicester, UK. It found that South Asian women with PCOS were younger at their first clinic appointment, smoked less, and had higher rates of Acanthosis Nigricans, type 2 diabetes, and hirsutism, but lower blood pressure and BMI compared to White women. Differences in body weight were significant even when adjusted for ethnicity-specific obesity thresholds. Age also influenced PCOS characteristics; women aged 30 or older had higher rates of obesity, type 2 diabetes, hypertension, and infertility, but less acne and oligomenorrhea. The study concluded that ethnicity, obesity, and age significantly affect the clinical presentation of PCOS, which should inform management strategies.
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