Significant Effects of Mild Endogenous Hormonal Changes in Humans: Considerations for Low-Dose Testing

March 2001 in “ Environmental Health Perspectives ”

Françoise Brucker-Davis, Kristina A. Thayer, Theo Colborn

endocrine-disrupting chemicals hormonal changes puberty stress nutrition exercise chronic disease osteoporosis cardiovascular disease cognitive changes hormonal interactions physiological hormone levels pathological hormone levels EDCs hormones heart disease brain function

TLDR Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

The document reviewed the health effects of small hormonal changes in humans, emphasizing the need for sensitive testing of endocrine-disrupting chemicals (EDCs). It discussed how normal physiological activities and conditions like puberty, stress, nutrition, exercise, and chronic disease can lead to hormonal changes that impact health. The paper highlighted the lack of a safe threshold for hormonal perturbations and the importance of considering low-dose exposures to EDCs. It also pointed out the need to focus on subtle health outcomes, such as osteoporosis, cardiovascular disease risk, and cognitive changes, when evaluating the effects of EDCs. The document underscored the complexity of hormonal interactions and the continuum between physiological and pathological hormone levels, challenging the establishment of medical thresholds for diagnosis and treatment.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Androgens and Women's Health

5 citations, June 1998 in “PubMed”

Excessive androgen in women can cause acne, hair growth, baldness, and PCOS, often treatable with medication.

Related Community Posts Join

6 / 118 results

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 1 year ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

community Is it me or are people losing their hair very young now?

in Finasteride/Dutasteride 143 upvotes 4 years ago

People notice more young individuals experiencing hair loss and discuss possible reasons, such as diet, hormones, and stress. Some treatments mentioned include finasteride, dutasteride, and minoxidil.

community Anyone else growing tired of the finasteride wars?

in Finasteride/Dutasteride 169 upvotes 1 year ago

The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

community Andrew Schulz stated he had been using a ‘’hair pill’’ for 15 years and it may have caused him infertility

in Satire 134 upvotes 1 year ago

The conversation discusses the potential link between hair loss treatment pills, specifically finasteride, and infertility. Users share their experiences and opinions, with some suggesting that finasteride can temporarily lower sperm count, while others argue that other factors like age and lifestyle could also contribute to infertility.

community Anyone else realize how many younger guys are balding?

in Chat 262 upvotes 1 month ago

Many younger men are experiencing hair loss due to genetics, diet, stress, and lifestyle changes. Treatments like finasteride and minoxidil are mentioned, with some users noting improvements.

community How is it that golden era bodybuilders kept their hair while blasting gear while in the modern era most are bald? I’m convinced there’s something in our food and water causing MPB to speed up

in Satire 723 upvotes 1 year ago

The conversation is about the difference in hair loss between bodybuilders in the "Golden Era" and modern bodybuilders. Some users speculate that factors such as the types and doses of steroids used, genetics, diet, microplastics, and overall health may contribute to hair loss. Hair loss prevention medication and transplants are mentioned as potential treatments.

Related Research

1 / 1 results

research Significant Effects of Mild Endogenous Hormonal Changes in Humans: Considerations for Low-Dose Testing

30 citations, March 2001 in “Environmental Health Perspectives”

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.